Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7

Shiyu Sun, Cen Cao, Yaru Guo, Yi Hou, Yanze Meng, Yuman Li, Feng Mei, Zhewen Hu, Yao Li, Yuting Niu, Yiming Chen, Lili Chen, Ying Huang, Xuliang Deng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Deceleration of sprouting angiogenesis until its final disappearance after blood vessel reconstruction is crucial for controlled tissue repair; however, its underlying mechanism remains unclear. It is reported that osteogenic differentiated bone marrow stem cells (OD-BMSCs) contribute to sprouting angiogenesis deceleration by releasing intrinsic “OFF” signals. In vitro experiments show that insulin-like growth factor-binding protein 7 (IGFBP7) is the main component of OD-BMSCs paracrine products which could inhibit the tube formation ability of endothelial cells. In addition, cell functional experiments show that IGFBP7 inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. Furthermore, it is found that early IGFBP7 intervention, which accelerates sprouting angiogenesis deceleration during the early stage of healing, impedes bone defect healing. These results demonstrate that OD-BMSCs could offer intrinsic inhibitory signals on sprouting angiogenesis and the appropriate emergence timing of these signals is crucial to maintain vasculature homeostasis during bone repairing. These results provide insight into the complex interaction between osteogenesis–angiogenesis coupling and suggest the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.

Original languageEnglish
Article number2201719
JournalAdvanced Materials Interfaces
Volume9
Issue number35
DOIs
StatePublished - 12 Dec 2022
Externally publishedYes

Keywords

  • endothelial cells (ECs)
  • insulin-like growth factor-binding protein 7 (IGFBP7)
  • osteogenic differentiated bone marrow stem cells (BMSCs)
  • paracrine effect
  • sprouting angiogenesis deceleration

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