Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

Liza Leventhal; John P. Mathis; Grace C. Rossi; Gavril W. Pasternak; Richard J. Bodnar

doi:10.1016/S0014-2999(98)00272-6

Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

Liza Leventhal
, John P. Mathis
, Grace C. Rossi
, Gavril W. Pasternak
, Richard J. Bodnar

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.

Original language	English
Pages (from-to)	R1-R3
Journal	European Journal of Pharmacology
Volume	349
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00272-6
State	Published - 15 May 1998
Externally published	Yes

Keywords

Hyperphagia
ORL1/KOR-3 clone
Orphanin FQ/nociceptin

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10.1016/S0014-2999(98)00272-6

Cite this

@article{1394ff9ed9c14682bb37fa18286d2e13,

title = "Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia",

abstract = "Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.",

keywords = "Hyperphagia, ORL1/KOR-3 clone, Orphanin FQ/nociceptin",

author = "Liza Leventhal and Mathis, \{John P.\} and Rossi, \{Grace C.\} and Pasternak, \{Gavril W.\} and Bodnar, \{Richard J.\}",

note = "Funding Information: This research was supported in part by NIDA grants DA05746 (LL), DA04194 (RJB), DA07274 (GWP) and DA00310 (GCR).",

year = "1998",

month = may,

day = "15",

doi = "10.1016/S0014-2999(98)00272-6",

language = "English",

volume = "349",

pages = "R1--R3",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

AU - Leventhal, Liza

AU - Mathis, John P.

AU - Rossi, Grace C.

AU - Pasternak, Gavril W.

AU - Bodnar, Richard J.

N1 - Funding Information: This research was supported in part by NIDA grants DA05746 (LL), DA04194 (RJB), DA07274 (GWP) and DA00310 (GCR).

PY - 1998/5/15

Y1 - 1998/5/15

N2 - Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.

AB - Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.

KW - Hyperphagia

KW - ORL1/KOR-3 clone

KW - Orphanin FQ/nociceptin

UR - https://www.scopus.com/pages/publications/0032524789

U2 - 10.1016/S0014-2999(98)00272-6

DO - 10.1016/S0014-2999(98)00272-6

M3 - Article

C2 - 9669488

AN - SCOPUS:0032524789

SN - 0014-2999

VL - 349

SP - R1-R3

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

Abstract

Keywords

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