Abstract
Dendritic cells (DC) are a system of bone marrow derived antigen presenting cells specialized for their interaction with T lymphocytes and essential for initiating primary T cell immune response. More heteregenous than originally thought, DC can be obtained from different hematopoietic lineage and diplay fonctionnal specialization that extend beyond the basic capacity to present antigen and activate T cells. Although under defined exprimental conditions DC can be derived from both myeloid and lymphoid progenitors in vitro, the pathways that lead to DC differenciation in vivo remain largely unknown. These pathways are now beginning to be mappped using cell tranfer approaches together with newer approaches employing genetically modified mice. In this review we will present the more relevant aspects of the literature in this field, and discuss the possible linkages between DC development origin and their functional diversity.
Translated title of the contribution | Dendritic cells origin |
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Original language | French |
Pages (from-to) | 429-439 |
Number of pages | 11 |
Journal | Hematologie |
Volume | 7 |
Issue number | 6 |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Antigen presentating cells
- Dendritic cells
- Dendritic cells ontogeny
- Immunotherapy
- Lymphoid dendritic cells
- Myeloid dendritic cells
- Plasmacytoid dendritic cells