Organizing genome engineering for the gigabase scale

Bryan A. Bartley, Jacob Beal, Jonathan R. Karr, Elizabeth A. Strychalski

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Genome-scale engineering holds great potential to impact science, industry, medicine, and society, and recent improvements in DNA synthesis have enabled the manipulation of megabase genomes. However, coordinating and integrating the workflows and large teams necessary for gigabase genome engineering remains a considerable challenge. We examine this issue and recommend a path forward by: 1) adopting and extending existing representations for designs, assembly plans, samples, data, and workflows; 2) developing new technologies for data curation and quality control; 3) conducting fundamental research on genome-scale modeling and design; and 4) developing new legal and contractual infrastructure to facilitate collaboration.

Original languageEnglish
Article number689
JournalNature Communications
Issue number1
StatePublished - 1 Dec 2020


Dive into the research topics of 'Organizing genome engineering for the gigabase scale'. Together they form a unique fingerprint.

Cite this