Organ donor screening practices for Strongyloides stercoralis infection among US organ procurement organizations

Francisca A. Abanyie, Emily Valice, Kristin W. Delli Carpini, Elizabeth B. Gray, Isabel McAuliffe, Peter V. Chin-Hong, Sukwan Handali, Susan P. Montgomery, Shirish Huprikar

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Background: Targeted donor screening for strongyloidiasis performed at the time of organ procurement can prevent this life-threatening donor-derived infection. Method: The Association of Organ Procurement Organizations surveyed members to determine the number of US organ procurement organizations (OPOs) performing donor screening for Strongyloides infection and their screening practices. Results: All 58 OPOs responded to the survey. Only 6 (10%) currently screen donors for strongyloidiasis; most OPOs started 6-36 months before the survey and one started 6 years prior. All used risk-based criteria to determine which donors to screen, though the criteria varied among OPOs. A median of 56 donors have been screened at each OPO since initiating their screening programs, with a median of 2 infected donors (range 0-13) identified. Overall, 53 organs have been transplanted from 22 infected donors, including hearts, lungs, kidneys, and livers. Of 52 OPOs not currently screening, 20 had considered screening and one plans to start screening in the near future. Of those considering risk-based screening, most had not decided on the criteria. Uncertainty about the benefits of and guidelines for screening and misconceptions about the interpretation of test results were concerns shared by non-screening OPOs. Conclusion: Continued education and advocacy on the importance of targeted donor screening are needed.

Original languageEnglish
Article numbere12865
JournalTransplant Infectious Disease
Volume20
Issue number3
DOIs
StatePublished - Jun 2018

Keywords

  • donor screening
  • donor-derived infection
  • parasitic infections
  • strongyloidiasis
  • transplant-associated infection

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