@article{9f27ef8fca3748198af48800d840081a,
title = "Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice",
abstract = "Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, domination of subordinate social targets is reinforcing. In this study, we showed that, in male mice, orexin neurons in the lateral hypothalamus activated a small population of glutamic acid decarboxylase 2 (GAD2)-expressing neurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) and that activation of these GAD2 neurons promoted male–male aggression and conditioned place preference for aggression-paired contexts. Moreover, LHb GAD2 neurons were inhibitory within the LHb and dampened the activity of the LHb as a whole. These results suggest that the orexin system is important for the regulation of inter-male aggressive behavior and provide the first functional evidence of a local inhibitory circuit within the LHb.",
author = "Flanigan, {Meghan E.} and Hossein Aleyasin and Long Li and Burnett, {C. Joseph} and Chan, {Kenny L.} and LeClair, {Katherine B.} and Lucas, {Elizabeth K.} and Bridget Matikainen-Ankney and {Durand-de Cuttoli}, Romain and Aki Takahashi and Caroline Menard and Pfau, {Madeline L.} and Golden, {Sam A.} and Sylvain Bouchard and Calipari, {Erin S.} and Nestler, {Eric J.} and DiLeone, {Ralph J.} and Akihiro Yamanaka and Huntley, {George W.} and Clem, {Roger L.} and Russo, {Scott J.}",
note = "Funding Information: The authors would like to thank S. Feng and C. Ferrer for their assistance with histology, N. Tzvaras for his assistance with microscopy and Virovek Inc. for cloning and packaging of AAV viruses. This work was supported by National Institutes of Health grants R01 MH114882-01 (to S.J.R.), R01 MH090264-06 (to S.J.R.), P50 MH096890 (to S.J.R.), P50 AT008661 (to S.J.R.), F31 MH111108-01A1 (to M.E.F.), T32 MH096678 (to M.E.F.), T32 MH087004 (to M.E.F.) and R01 MH51399 (to E.J.N.). Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2020",
month = may,
day = "1",
doi = "10.1038/s41593-020-0617-7",
language = "English",
volume = "23",
pages = "638--650",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "5",
}