Oral tolerance to dietary antigens and Foxp3+ regulatory T cells

Mariana C.G. Miranda-Waldetario, Maria A. Curotto de Lafaille

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Immune tolerance to foods develops in the intestine upon food ingestion and is essential to prevent IgE-mediated food allergy and gut inflammation. In homeostasis, the intestine is a tolerogenic environment that favors the formation of food-specific Foxp3+ regulatory T cells. A tolerogenic intestinal environment depends on colonization by diverse microbiota and exposure to solid foods at a critical period in early life. These early immune responses lead to the induction of antigen-specific Foxp3+ regulatory T cells in draining mesenteric lymph nodes. These peripherally induced regulatory cells circulate and seed the lamina propria of the gut, exerting suppressive function systemically and locally in the intestine. Successful establishment of a tolerogenic intestinal environment in early life sets the stage for oral tolerance to new antigens in adult life.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalImmunological Reviews
Volume326
Issue number1
DOIs
StatePublished - Sep 2024

Keywords

  • Foxp3 Tregs
  • IgE
  • food allergy
  • oral tolerance

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