Oral tolerance and oral immunotherapy for food allergy: Evidence for common mechanisms?

Wajiha Kazmi, M. Cecilia Berin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Food allergies affect up to 10% of the US population, can be life-threatening, and have a significant negative impact on quality of life. Delayed dietary introduction of foods in childhood can hinder the induction of oral tolerance, an active regulatory response to foods that prevents the development of food allergy. Some children outgrow their food allergies naturally, while many others have persistent, lifelong food allergy for which there are few therapeutic options. Oral immunotherapy (OIT) is a therapeutic approach of giving increasing amounts of food to attempt to desensitize the allergic individual. In this review, we focus on the immune mechanisms common to oral tolerance and response to oral immunotherapy, with the objective of determining whether true tolerance can be achieved after food allergy has been established.

Original languageEnglish
Article number104650
JournalCellular Immunology
Volume383
DOIs
StatePublished - Jan 2023

Fingerprint

Dive into the research topics of 'Oral tolerance and oral immunotherapy for food allergy: Evidence for common mechanisms?'. Together they form a unique fingerprint.

Cite this