Oral immunotherapy for food allergy: Mechanisms and role in management

A. Nowak-Wegrzyn, S. Albin

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Summary: With the emergence of food allergy as an important public health problem, it has become clear that there is an unmet need in regard to treatment. In particular, IgE-mediated food allergy that is associated with risk of fatal anaphylaxis has been the subject of multiple studies in the past decade. The growing body of evidence derived from multiple centres and various study designs indicates that for IgE-mediated food allergy, immunomodulation through food immunotherapy is possible; however, the extent of protection afforded by such treatment is highly variable. At this time, the capacity for food immunotherapy to restore permanent tolerance to food has not been demonstrated conclusively. This review will discuss these topics as they apply to the most important studies of food oral immunotherapy.

Original languageEnglish
Pages (from-to)368-383
Number of pages16
JournalClinical and Experimental Allergy
Volume45
Issue number2
DOIs
StatePublished - 1 Feb 2015

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