Oral contraceptives and in vivo cytogenetic studies

Lawrence R. Shapiro, Zoe R. Graves, Kurt Hirschhorn

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Cytogenetic studies of peripheral blood lymphocyte cultures were done on 7 young women prior to and after 1 and 2 months of oral contraceptive use. No significant change in chromosome breaks or mitotic index was revealed when each of the 7 women served as her own control nor when findings in 4 additional young women who had been using oral contraceptives for more than 3 years were compared to those from 4 controls. These results differ from several other studies in vivo which did not use each patient as her own control.

Original languageEnglish
Pages (from-to)190-192
Number of pages3
JournalObstetrics and Gynecology
Issue number2
StatePublished - Feb 1972


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