TY - JOUR
T1 - Oral contraceptive use and prevalence of self-reported glaucoma or ocular hypertension in the United States
AU - Wang, Ye Elaine
AU - Kakigi, Caitlin
AU - Barbosa, Diego
AU - Porco, Travis
AU - Chen, Rebecca
AU - Wang, Sophia
AU - Li, Yingjie
AU - Singh, Kuldev
AU - Pasquale, Louis R.
AU - Lin, Shan C.
N1 - Publisher Copyright:
© 2016 by the American Academy of Ophthalmology Published by Elsevier Inc.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose To investigate the association between oral contraceptive (OC) use and glaucoma prevalence in the United States. Design Cross-sectional study. Participants A total of 3406 female participants, aged 40 years or older, from the 2005 to 2008 National Health and Nutrition Examination Survey, who reported a presence or absence of glaucoma or ocular hypertension completed both the vision and the reproductive health questionnaires and underwent eye examinations. Methods Multivariate regression analysis was used to assess the correlation between OC use and self-reported glaucoma or ocular hypertension (n = 231 cases), controlling for potential confounders, including age, ethnicity, systemic comorbidities such as hypertension and stroke, ocular diseases such as cataract and diabetic retinopathy, and reproductive health factors, including age at menopause, age at menarche, history of hormone replacement therapy, and gynecological surgical history. Main Outcome Measures The outcome variable was self-reported glaucoma or ocular hypertension. Results After adjusting for confounders, those with ≥3 years of OC use had greater odds (odds ratio, 1.94; 95% confidence interval, 1.22-3.07) of self-reported glaucoma or ocular hypertension. Other factors associated with higher glaucoma or ocular hypertension prevalence included older age, African American race, and later age at menarche. Conclusions Oral contraceptive use may be associated with increased risk of self-reported glaucoma or ocular hypertension.
AB - Purpose To investigate the association between oral contraceptive (OC) use and glaucoma prevalence in the United States. Design Cross-sectional study. Participants A total of 3406 female participants, aged 40 years or older, from the 2005 to 2008 National Health and Nutrition Examination Survey, who reported a presence or absence of glaucoma or ocular hypertension completed both the vision and the reproductive health questionnaires and underwent eye examinations. Methods Multivariate regression analysis was used to assess the correlation between OC use and self-reported glaucoma or ocular hypertension (n = 231 cases), controlling for potential confounders, including age, ethnicity, systemic comorbidities such as hypertension and stroke, ocular diseases such as cataract and diabetic retinopathy, and reproductive health factors, including age at menopause, age at menarche, history of hormone replacement therapy, and gynecological surgical history. Main Outcome Measures The outcome variable was self-reported glaucoma or ocular hypertension. Results After adjusting for confounders, those with ≥3 years of OC use had greater odds (odds ratio, 1.94; 95% confidence interval, 1.22-3.07) of self-reported glaucoma or ocular hypertension. Other factors associated with higher glaucoma or ocular hypertension prevalence included older age, African American race, and later age at menarche. Conclusions Oral contraceptive use may be associated with increased risk of self-reported glaucoma or ocular hypertension.
UR - http://www.scopus.com/inward/record.url?scp=84959423271&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2015.11.029
DO - 10.1016/j.ophtha.2015.11.029
M3 - Article
C2 - 26948305
AN - SCOPUS:84959423271
SN - 0161-6420
VL - 123
SP - 729
EP - 736
JO - Ophthalmology
JF - Ophthalmology
IS - 4
ER -