Oral cobalamin remains medicine's best kept secret

Ian D. Graham, Nathalie Jette, Jacqueline Tetroe, Nicole Robinson, Sarah Milne, Susan L. Mitchell

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A cross-sectional survey was conducted in order to describe the use of oral cobalamin among geriatricians, hematologists, and general practitioners, and to explore factors related to its use. The study population consisted of all geriatricians (n = 138) and hematologists (n = 317) listed in the Canadian Medical Directory plus a random sample of 307 general practitioners. The overall response rate was 40%. Intramuscular and oral cobalamin was prescribed by 76 and 32% of the respondents, respectively. Twenty seven percent reported using both oral and intramuscular cobalamin and 6% reported using only oral cobalamin. Only 25% of respondents indicated they were aware of a RCT demonstrating the efficacy of oral cobalamin prior to reading a synopsis of the study in the survey. After multivariate adjustment, only the belief that oral cobalamin was effective and certainty about who carried oral preparations remained independently associated with oral cobalamin use. Oral cobalamin has been shown to be an efficacious, cost efficient and safe method of treating cobalamin deficiency. Nonetheless, it is not used by the majority of physicians treating this condition. Strategies to promote the use of oral cobalamin should be directed at educating physicians of its efficacy and providing them with prescribing information on where it can be purchased.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalArchives of Gerontology and Geriatrics
Issue number1
StatePublished - Jan 2007
Externally publishedYes


  • Evidence-based practice
  • Oral cobalamin
  • Survey of oral cobalamin treatments


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