Optogenetic investigation of neural mechanisms for alcohol-use disorder

Barbara Juarez, Yutong Liu, Lu Zhang, Ming Hu Han

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Optogenetic techniques have been widely used in the study of neuropsychiatric diseases such as anxiety, depression, and drug addiction. Cell-type specific targeting of optogenetic tools to neurons has contributed to a tremendous understanding of the function of neural circuits for future treatment of neuropsychiatric disorders. Though optogenetics has been widely used in many research areas, the use of optogenetic tools to uncover and elucidate neural circuit mechanisms of alcohol's actions in the brain are still developing. Here in this review article, we will provide a basic introduction to optogenetics and discuss how these optogenetic experimental approaches can be used in alcohol studies to reveal neural circuit mechanisms of alcohol's actions in regions implicated in the development of alcohol addiction.

Original languageEnglish
Pages (from-to)29-38
Number of pages10
JournalAlcohol
Volume74
DOIs
StatePublished - Feb 2019

Keywords

  • Alcohol-use disorder
  • Neural circuit
  • Optogenetics

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