TY - JOUR
T1 - Optical Coherence Tomography of Coronary Plaque Progression and Destabilization
T2 - JACC Focus Seminar Part 3/3
AU - Adriaenssens, Tom
AU - Allard-Ratick, Marc P.
AU - Thondapu, Vikas
AU - Sugiyama, Tomoyo
AU - Raffel, O. Christopher
AU - Barlis, Peter
AU - Poon, Eric K.W.
AU - Araki, Makoto
AU - Nakajima, Akihiro
AU - Minami, Yoshiyasu
AU - Takano, Masamichi
AU - Kurihara, Osamu
AU - Fuster, Valentin
AU - Kakuta, Tsunekazu
AU - Jang, Ik Kyung
N1 - Publisher Copyright:
© 2021 American College of Cardiology Foundation
PY - 2021/9/21
Y1 - 2021/9/21
N2 - The development of optical coherence tomography (OCT) has revolutionized our understanding of coronary artery disease. In vivo OCT research has paralleled with advances in computational fluid dynamics, providing additional insights in the various hemodynamic factors influencing plaque growth and stability. Recent OCT studies introduced a new concept of plaque healing in relation to clinical presentation. In addition to known mechanisms of acute coronary syndromes such as plaque rupture and plaque erosion, a new classification of calcified plaque was recently reported. This review will focus on important new insights that OCT has provided in recent years into coronary plaque development, progression, and destabilization, with a focus on the role of local hemodynamics and endothelial shear stress, the layered plaque (signature of previous subclinical plaque destabilization and healing), and the calcified culprit plaque.
AB - The development of optical coherence tomography (OCT) has revolutionized our understanding of coronary artery disease. In vivo OCT research has paralleled with advances in computational fluid dynamics, providing additional insights in the various hemodynamic factors influencing plaque growth and stability. Recent OCT studies introduced a new concept of plaque healing in relation to clinical presentation. In addition to known mechanisms of acute coronary syndromes such as plaque rupture and plaque erosion, a new classification of calcified plaque was recently reported. This review will focus on important new insights that OCT has provided in recent years into coronary plaque development, progression, and destabilization, with a focus on the role of local hemodynamics and endothelial shear stress, the layered plaque (signature of previous subclinical plaque destabilization and healing), and the calcified culprit plaque.
KW - acute coronary syndrome
KW - calcified plaque
KW - endothelial shear stress
KW - layered plaque
KW - optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85114113467&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2021.07.032
DO - 10.1016/j.jacc.2021.07.032
M3 - Review article
C2 - 34531029
AN - SCOPUS:85114113467
SN - 0735-1097
VL - 78
SP - 1275
EP - 1287
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 12
ER -