TY - JOUR
T1 - Optical coherence tomography angiography analysis of perfused peripapillary capillaries in primary open-angle glaucoma and normal-tension glaucoma
AU - Scripsema, Nicole K.
AU - Garcia, Patricia M.
AU - Bavier, Richard D.
AU - Chui, Toco Y.P.
AU - Krawitz, Brian D.
AU - Mo, Shelley
AU - Agemy, Steven A.
AU - Xu, Luna
AU - Lin, Yijie B.
AU - Panarelli, Joseph F.
AU - Sidoti, Paul A.
AU - Tsai, James C.
AU - Rosen, Richard B.
N1 - Funding Information:
The authors thank the two anonymous reviewers for their helpful suggestions and comments. Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY, USA. PAS receives support from the David E. Marrus Glaucoma Research Fund and the Herman Peters Pediatric Glaucoma Research Fund of the New York Eye and Ear Infirmary of Mount Sinai.
Publisher Copyright:
© 2016 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.
PY - 2016/7
Y1 - 2016/7
N2 - PURPOSE. To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). METHODS. A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3.5- and 4.5-mm-diameter scans. We compared PCD values, PCD maps, standard automated perimetry (Humphrey visual field [HVF]) parameters, and OCT retinal nerve fiber layer (RNFL) thickness analyses across all groups. RESULTS. Forty POAG, 26 NTG, and 26 normal patients were included. Annular PCD in POAG (34.24 6 6.76%) and NTG (37.75 6 3.52%) patients was significantly decreased compared to normal patients (42.99 6 1.81%) in 4.5-mm scans (P < 0.01 and P < 0.01, respectively). Similar trends and statistical significances were seen in 3.5-mm scans. Linear regression analysis resulted in moderate correlations between annular PCD values and other glaucomatous parameters. Pearson coefficients comparing annular PCD from 4.5-mm scans in POAG and NTG groups to HVF mean deviation, HVF pattern standard deviation, and average RNFL thickness all showed statistical significance (P < 0.05). Color maps showed that POAG and NTG patients had a reduction of perfused capillaries that progressed in size when comparing early, moderate, and severe glaucoma groups. CONCLUSIONS. Optical coherence tomography angiography can uniquely identify changes in peripapillary PCD in glaucoma patients. Optical coherence tomography angiography may offer insights into the pathophysiology of glaucomatous damage and risk factors for disease progression.
AB - PURPOSE. To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). METHODS. A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3.5- and 4.5-mm-diameter scans. We compared PCD values, PCD maps, standard automated perimetry (Humphrey visual field [HVF]) parameters, and OCT retinal nerve fiber layer (RNFL) thickness analyses across all groups. RESULTS. Forty POAG, 26 NTG, and 26 normal patients were included. Annular PCD in POAG (34.24 6 6.76%) and NTG (37.75 6 3.52%) patients was significantly decreased compared to normal patients (42.99 6 1.81%) in 4.5-mm scans (P < 0.01 and P < 0.01, respectively). Similar trends and statistical significances were seen in 3.5-mm scans. Linear regression analysis resulted in moderate correlations between annular PCD values and other glaucomatous parameters. Pearson coefficients comparing annular PCD from 4.5-mm scans in POAG and NTG groups to HVF mean deviation, HVF pattern standard deviation, and average RNFL thickness all showed statistical significance (P < 0.05). Color maps showed that POAG and NTG patients had a reduction of perfused capillaries that progressed in size when comparing early, moderate, and severe glaucoma groups. CONCLUSIONS. Optical coherence tomography angiography can uniquely identify changes in peripapillary PCD in glaucoma patients. Optical coherence tomography angiography may offer insights into the pathophysiology of glaucomatous damage and risk factors for disease progression.
KW - Angiography
KW - Glaucoma posterior segment
KW - Low-tension glaucoma
KW - Optic nerve head
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85013945977&partnerID=8YFLogxK
U2 - 10.1167/IOVS.15-18945
DO - 10.1167/IOVS.15-18945
M3 - Article
C2 - 27742922
AN - SCOPUS:85013945977
SN - 0146-0404
VL - 57
SP - OCT611-OTC620
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 9
ER -