Optical coherence tomography and coronary revascularization: from indication to procedural optimization

Rick Volleberg, Jan Quinten Mol, Dirk van der Heijden, Martijn Meuwissen, Maarten van Leeuwen, Javier Escaned, Niels Holm, Tom Adriaenssens, Robert Jan van Geuns, Shengxian Tu, Filippo Crea, Gregg Stone, Niels van Royen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Angiography alone is the most commonly used imaging modality for guidance of percutaneous coronary interventions. Angiography is limited, however, by several factors, including that it only portrays a low resolution, two-dimensional outline of the lumen and does not inform on plaque composition and functional stenosis severity. Optical coherence tomography (OCT) is an intracoronary imaging technique that has superior spatial resolution compared to all other imaging modalities. High-resolution imaging of the vascular wall enables precise measurement of vessel wall and luminal dimensions, more accurately informing about the anatomic severity of epicardial stenoses, and also provides input for computational models to assess functional severity. The very high-resolution images also permit plaque characterization that may be informative for prognostication. Moreover, periprocedural imaging provides valuable information to guide lesion preparation, stent implantation and to evaluate acute stent complications for which iterative treatment might reduce the occurrence of major adverse stent events. As such, OCT represent a potential future all-in-one tool that provides the data necessary to establish the indications, procedural planning and optimization, and final evaluation of percutaneous coronary revascularization.

Original languageEnglish
Pages (from-to)92-106
Number of pages15
JournalTrends in Cardiovascular Medicine
Issue number2
StatePublished - Feb 2023


  • Coronary artery disease
  • Intravascular imaging
  • Myocardial infarction
  • Optical coherence tomography
  • Percutaneous revascularization
  • Procedural guidance
  • State-of-the-art
  • Vulnerable plaque


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