Opportunistic infections and immune deficiency in homosexual men

D. Mildvan, U. Mathur, R. W. Enlow, P. L. Romain, R. J. Winchester, C. Colp, H. Singman, B. R. Adelsberg, I. Spigland

Research output: Contribution to journalArticlepeer-review

248 Scopus citations


A syndrome of opportunistic infections and acquired immune deficiency occurred among four previously healthy homosexual men. Fever, leukopenia, and diminished delayed hypersensitivity were accompanied by various degrees of proctitis, perianal ulcerations, and lymphadenopathy. The infectious agents included Pneumocystis carinii, Cryptococcus neoformans, Candida albicans, herpes simplex virus, and cytomegalovirus. The immune deficiency was characterized as a persistent and profound selective decrease in the function as well as number of T lymphocytes of the helper/inducer subset and a possible activation of the suppressor/cytotoxic subset. Three patients died despite aggressive anti-infective therapy.

Original languageEnglish
Pages (from-to)700-704
Number of pages5
JournalUnknown Journal
Issue number6 I
StatePublished - 1982


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