Opossum insulin, glucagon and pancreatic polypeptide: Amino acid sequences

J. H. Yu; J. Eng; S. Rattan; R. S. Yalow

doi:10.1016/0196-9781(89)90012-0

Opossum insulin, glucagon and pancreatic polypeptide: Amino acid sequences

J. H. Yu, J. Eng, S. Rattan, R. S. Yalow

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14 Scopus citations

Abstract

Pancreatic hormones have been purified from the opossum, a New World marsupial. Opossum insulin contains a Leu substitution at the N-terminus of the B-chain in place of the Phe that is generally present in mammalian insulins. In addition, there are two other amino acid substitutions in the opossum insulin A-chain (positions 8 and 18) compared to pig insulin. Opossum glucagon is identical to chicken glucagon with both differing from the usual mammalian glucagon by Ser in place of Asn at its penultimate C-terminal position. Opossum PP differs from the porcine peptide in only 3 sites (position 3, 19 and 30).

Original language	English
Pages (from-to)	1195-1197
Number of pages	3
Journal	Peptides
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(89)90012-0
State	Published - 1989
Externally published	Yes

Keywords

Amino acid sequence
Glucagon
Insulin
New World marsupial
Opossum
Pancreatic polypeptide

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10.1016/0196-9781(89)90012-0

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title = "Opossum insulin, glucagon and pancreatic polypeptide: Amino acid sequences",

abstract = "Pancreatic hormones have been purified from the opossum, a New World marsupial. Opossum insulin contains a Leu substitution at the N-terminus of the B-chain in place of the Phe that is generally present in mammalian insulins. In addition, there are two other amino acid substitutions in the opossum insulin A-chain (positions 8 and 18) compared to pig insulin. Opossum glucagon is identical to chicken glucagon with both differing from the usual mammalian glucagon by Ser in place of Asn at its penultimate C-terminal position. Opossum PP differs from the porcine peptide in only 3 sites (position 3, 19 and 30).",

keywords = "Amino acid sequence, Glucagon, Insulin, New World marsupial, Opossum, Pancreatic polypeptide",

author = "Yu, {J. H.} and J. Eng and S. Rattan and Yalow, {R. S.}",

note = "Funding Information: This work was supported in part by the Medical Research Program of the Veterans Administration. J.-H. Yu is a Fellow of the Solomon A. Berson Fund for Medical Research, Inc. We want to acknowledge with thanks Dr. Ronald Chance of Lilly Research Laboratory (Indianapolis, IN) who provided us with the rabbit antibeef PP antiserum (615-R110-146-10) and beef PP. The opossum pancreas was made available through NIH grant, DK-35385, to Dr. Rattan.",

year = "1989",

doi = "10.1016/0196-9781(89)90012-0",

language = "English",

volume = "10",

pages = "1195--1197",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "6",

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TY - JOUR

T1 - Opossum insulin, glucagon and pancreatic polypeptide

T2 - Amino acid sequences

AU - Yu, J. H.

AU - Eng, J.

AU - Rattan, S.

AU - Yalow, R. S.

N1 - Funding Information: This work was supported in part by the Medical Research Program of the Veterans Administration. J.-H. Yu is a Fellow of the Solomon A. Berson Fund for Medical Research, Inc. We want to acknowledge with thanks Dr. Ronald Chance of Lilly Research Laboratory (Indianapolis, IN) who provided us with the rabbit antibeef PP antiserum (615-R110-146-10) and beef PP. The opossum pancreas was made available through NIH grant, DK-35385, to Dr. Rattan.

PY - 1989

Y1 - 1989

N2 - Pancreatic hormones have been purified from the opossum, a New World marsupial. Opossum insulin contains a Leu substitution at the N-terminus of the B-chain in place of the Phe that is generally present in mammalian insulins. In addition, there are two other amino acid substitutions in the opossum insulin A-chain (positions 8 and 18) compared to pig insulin. Opossum glucagon is identical to chicken glucagon with both differing from the usual mammalian glucagon by Ser in place of Asn at its penultimate C-terminal position. Opossum PP differs from the porcine peptide in only 3 sites (position 3, 19 and 30).

AB - Pancreatic hormones have been purified from the opossum, a New World marsupial. Opossum insulin contains a Leu substitution at the N-terminus of the B-chain in place of the Phe that is generally present in mammalian insulins. In addition, there are two other amino acid substitutions in the opossum insulin A-chain (positions 8 and 18) compared to pig insulin. Opossum glucagon is identical to chicken glucagon with both differing from the usual mammalian glucagon by Ser in place of Asn at its penultimate C-terminal position. Opossum PP differs from the porcine peptide in only 3 sites (position 3, 19 and 30).

KW - Amino acid sequence

KW - Glucagon

KW - Insulin

KW - New World marsupial

KW - Opossum

KW - Pancreatic polypeptide

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U2 - 10.1016/0196-9781(89)90012-0

DO - 10.1016/0196-9781(89)90012-0

M3 - Article

C2 - 2695899

AN - SCOPUS:0024789928

SN - 0196-9781

VL - 10

SP - 1195

EP - 1197

JO - Peptides

JF - Peptides

IS - 6

ER -

Opossum insulin, glucagon and pancreatic polypeptide: Amino acid sequences

Abstract

Keywords

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