Opossum insulin, glucagon and pancreatic polypeptide: Amino acid sequences

J. H. Yu, J. Eng, S. Rattan, R. S. Yalow

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Pancreatic hormones have been purified from the opossum, a New World marsupial. Opossum insulin contains a Leu substitution at the N-terminus of the B-chain in place of the Phe that is generally present in mammalian insulins. In addition, there are two other amino acid substitutions in the opossum insulin A-chain (positions 8 and 18) compared to pig insulin. Opossum glucagon is identical to chicken glucagon with both differing from the usual mammalian glucagon by Ser in place of Asn at its penultimate C-terminal position. Opossum PP differs from the porcine peptide in only 3 sites (position 3, 19 and 30).

Original languageEnglish
Pages (from-to)1195-1197
Number of pages3
Issue number6
StatePublished - 1989
Externally publishedYes


  • Amino acid sequence
  • Glucagon
  • Insulin
  • New World marsupial
  • Opossum
  • Pancreatic polypeptide


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