OpenVax: An open-source computational pipeline for cancer neoantigen prediction

Julia Kodysh, Alex Rubinsteyn

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

20 Scopus citations

Abstract

OpenVax is a computational workflow for identifying somatic variants, predicting neoantigens, and selecting the contents of personalized cancer vaccines. It is a Dockerized end-to-end pipeline that takes as input raw tumor/normal sequencing data. It is currently used in three clinical trials (NCT02721043, NCT03223103, and NCT03359239). In this chapter, we describe how to install and use OpenVax, as well as how to interpret the generated results.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages147-160
Number of pages14
DOIs
StatePublished - 2020

Publication series

NameMethods in Molecular Biology
Volume2120
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Bioinformatics pipeline
  • Cancer vaccine
  • Docker
  • Immunoinformatics
  • NGS
  • Neoantigen

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