Opening lines of communication in the distal nephron

Thomas R. Kleyman, Lisa M. Satlin, Kenneth R. Hallows

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The distal nephron is composed of two main cell types: principal cells and intercalated cells. These cells have distinct morphologic features that allow them to be readily distinguished by light microscopy, as well as distinct suites of proteins that facilitate cell-specific transport properties. In this issue of the JCI, Gueutin and colleagues describe a new mechanism by which β-intercalated cells, via release of ATP and prostaglandin E2(PGE2), influence the activity of transporters in principal cells.

Original languageEnglish
Pages (from-to)4139-4141
Number of pages3
JournalJournal of Clinical Investigation
Issue number10
StatePublished - 1 Oct 2013


Dive into the research topics of 'Opening lines of communication in the distal nephron'. Together they form a unique fingerprint.

Cite this