Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

Attila Toth, Rolf Jessberger

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

Original languageEnglish
Pages (from-to)R329-R331
JournalCurrent Biology
Volume26
Issue number8
DOIs
StatePublished - 25 Apr 2016
Externally publishedYes

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