Ontogeny of human Ia antigens

P. G. Natali; C. Russo; A. K. Ng; M. R. Nicotra; C. Apollonj; M. A. Pellegrino; S. Ferrone

doi:10.1016/0008-8749(82)90465-8

Ontogeny of human Ia antigens

P. G. Natali, C. Russo, A. K. Ng, M. R. Nicotra, C. Apollonj, M. A. Pellegrino, S. Ferrone

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Indirect immunofluorescence (IIP) staining of tissues from human fetuses (ages ranging from 8 to 32 weeks of intrauterine life) with monoclonal antibodies (MoAb) to monomorphic determinants of Ia antigens and HLA-A,B,C antigens has shown that both types of antigens are already detectable in tissues of 8-week-old fetuses. Ia antigens and HLA-A,B,C antigens reach their almost-complete tissue distribution after 32 and 24 weeks of intrauterine life, respectively. The structure of Ia antigens synthesized by fetal thymus cells is similar to that of B-lymphoid cell-derived Ia antigens. Ia antigen-bearing thymic fetal cells can stimulate allogeneic lymphocytes in mixed lymphocyte reactions (MLRs). These reactions are blocked by monoclonal antibodies to monomorphic determinants of human Ia antigens and of HLA-A,B, antigens.

Original language	English
Pages (from-to)	385-396
Number of pages	12
Journal	Cellular Immunology
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(82)90465-8
State	Published - 1 Nov 1982
Externally published	Yes

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@article{5b7ca9a019ea4eb3a1825eed0209f258,

title = "Ontogeny of human Ia antigens",

abstract = "Indirect immunofluorescence (IIP) staining of tissues from human fetuses (ages ranging from 8 to 32 weeks of intrauterine life) with monoclonal antibodies (MoAb) to monomorphic determinants of Ia antigens and HLA-A,B,C antigens has shown that both types of antigens are already detectable in tissues of 8-week-old fetuses. Ia antigens and HLA-A,B,C antigens reach their almost-complete tissue distribution after 32 and 24 weeks of intrauterine life, respectively. The structure of Ia antigens synthesized by fetal thymus cells is similar to that of B-lymphoid cell-derived Ia antigens. Ia antigen-bearing thymic fetal cells can stimulate allogeneic lymphocytes in mixed lymphocyte reactions (MLRs). These reactions are blocked by monoclonal antibodies to monomorphic determinants of human Ia antigens and of HLA-A,B, antigens.",

author = "Natali, {P. G.} and C. Russo and Ng, {A. K.} and Nicotra, {M. R.} and C. Apollonj and Pellegrino, {M. A.} and S. Ferrone",

note = "Funding Information: This work was supported by National Institutes of Health Grants Al 19189, CA 32609, CA 32619, CA 32634, CA 32635, S-07RR05395-2 I, and Programma Finalizzato “Controllo della Crescita Neoplastica” CNR 8 10132696.C arlo Russo is a recipient of a Special Fellowship of the Leukemia Society of America. Michele A. Pellegrino is the recipient of a Research Career Development Award (CA 00846) from the National Cancer Institute, DHHS. The authors greatly appreciate the excellent secretarial assistance of Mrs. C. Gama.",

year = "1982",

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doi = "10.1016/0008-8749(82)90465-8",

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T1 - Ontogeny of human Ia antigens

AU - Natali, P. G.

AU - Russo, C.

AU - Ng, A. K.

AU - Nicotra, M. R.

AU - Apollonj, C.

AU - Pellegrino, M. A.

AU - Ferrone, S.

N1 - Funding Information: This work was supported by National Institutes of Health Grants Al 19189, CA 32609, CA 32619, CA 32634, CA 32635, S-07RR05395-2 I, and Programma Finalizzato “Controllo della Crescita Neoplastica” CNR 8 10132696.C arlo Russo is a recipient of a Special Fellowship of the Leukemia Society of America. Michele A. Pellegrino is the recipient of a Research Career Development Award (CA 00846) from the National Cancer Institute, DHHS. The authors greatly appreciate the excellent secretarial assistance of Mrs. C. Gama.

PY - 1982/11/1

Y1 - 1982/11/1

N2 - Indirect immunofluorescence (IIP) staining of tissues from human fetuses (ages ranging from 8 to 32 weeks of intrauterine life) with monoclonal antibodies (MoAb) to monomorphic determinants of Ia antigens and HLA-A,B,C antigens has shown that both types of antigens are already detectable in tissues of 8-week-old fetuses. Ia antigens and HLA-A,B,C antigens reach their almost-complete tissue distribution after 32 and 24 weeks of intrauterine life, respectively. The structure of Ia antigens synthesized by fetal thymus cells is similar to that of B-lymphoid cell-derived Ia antigens. Ia antigen-bearing thymic fetal cells can stimulate allogeneic lymphocytes in mixed lymphocyte reactions (MLRs). These reactions are blocked by monoclonal antibodies to monomorphic determinants of human Ia antigens and of HLA-A,B, antigens.

AB - Indirect immunofluorescence (IIP) staining of tissues from human fetuses (ages ranging from 8 to 32 weeks of intrauterine life) with monoclonal antibodies (MoAb) to monomorphic determinants of Ia antigens and HLA-A,B,C antigens has shown that both types of antigens are already detectable in tissues of 8-week-old fetuses. Ia antigens and HLA-A,B,C antigens reach their almost-complete tissue distribution after 32 and 24 weeks of intrauterine life, respectively. The structure of Ia antigens synthesized by fetal thymus cells is similar to that of B-lymphoid cell-derived Ia antigens. Ia antigen-bearing thymic fetal cells can stimulate allogeneic lymphocytes in mixed lymphocyte reactions (MLRs). These reactions are blocked by monoclonal antibodies to monomorphic determinants of human Ia antigens and of HLA-A,B, antigens.

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VL - 73

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JO - Cellular Immunology

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Ontogeny of human Ia antigens

Abstract

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