Onset of Action of Antipsoriatic Drugs for Moderate-to-Severe Plaque Psoriasis:An Update

Christopher J. Yao, Mark G. Lebwohl

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objectives: The time that drugs for moderate-to-severe psoriasis take to see a clinically meaningful improvement (TOA) is one of the most important attributes of treatment success. This study synthesizes TOA data from previously reviewed drugs and adds clinical data for tidrakizumab and certolizumab pegol for comparison. Methods: We reviewed published and presented efficacy data regarding TOA, which was defined as the time at which 25% of the sample population reached Psoriasis Area and Severity Index (PASI) 75 or the time at which the sample population reached a mean PASI 50. Results: Antipsoriatic drugs obtained clinically meaningful outcomes within 1.8-25.4 w, and brodalumab had the fastest TOA for both outcome measures. Conclusion: Brodalumab may continue to have the most rapid onset of action of available antipsoriatic therapies.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalJournal of Drugs in Dermatology
Volume18
Issue number3
StatePublished - Mar 2019

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