One-Year Follow-up of Infants With Abstinence-Associated Seizures

Tatiana M. Doberczak, Stefan Shanzer, Rhoda Cutler, Ruby T. Senie, Joanna A. Loucopoulos, Stephen R. Kandall

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Fourteen infants with neonatal abstinence-associated seizures were assessed neurodevelopmentally during the first year of life. Despite abnormal neurologic examination results in eight of 12 infants at 2 to 4 months of age, nine of 12 infants had normal neurologic examination results at follow-up (two infants were unavailable for follow-up; one infant died of acquired immunodeficiency syndrome). Nine neonatal electroencephalograms were abnormal; seven of eight of these abnormal tracings normalized during the follow-up period. Bayley developmental scores remained normal during the first year of life and did not differ from either passively addicted infants without seizures or from published population norms. This short-term favorable prognosis for abstinence-associated seizures differs from that associated with neonatal seizures due to other causes. This observed improvement in neurologic function may be based on replenishment of neurotransmitters following transient depletion in the neonatal period.

Original languageEnglish
Pages (from-to)649-653
Number of pages5
JournalArchives of Neurology
Volume45
Issue number6
DOIs
StatePublished - Jun 1988

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