One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide

Jia Ming Li; Zhi Yong Wang; Lei Zeng; Ming Ming Zhou

One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide

Jia Ming Li, Zhi Yong Wang, Lei Zeng, Ming Ming Zhou

Research output: Contribution to journal › Article › peer-review

Abstract

One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide was realized by the reaction of 5-amino-2, 2-dimethyl-1,3-dioxane with acetic anhydride in high regioselectivity and yield with easiness for operation under mild condition. The structures of the products were identified with FTIR, ¹H NMR, ¹³C NMR and HRMS spectra. Compound 4, which should be a potential inhibitor of HIV-1 Tat/PCAF BRD association, can be synthesized from N-3-(1,3-dihydroxyprop-2-yl)propylacetamide easily.

Original language	English
Pages (from-to)	971-974
Number of pages	4
Journal	Chinese Journal of Organic Chemistry
Volume	26
Issue number	7
State	Published - Jul 2006

Keywords

Acetic anhydride
Highly selective acylation
N-1,3-dihydroxyprop-2-ylalkylacetamide
One-pot synthesis

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title = "One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide",

abstract = "One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide was realized by the reaction of 5-amino-2, 2-dimethyl-1,3-dioxane with acetic anhydride in high regioselectivity and yield with easiness for operation under mild condition. The structures of the products were identified with FTIR, 1H NMR, 13C NMR and HRMS spectra. Compound 4, which should be a potential inhibitor of HIV-1 Tat/PCAF BRD association, can be synthesized from N-3-(1,3-dihydroxyprop-2-yl)propylacetamide easily.",

keywords = "Acetic anhydride, Highly selective acylation, N-1,3-dihydroxyprop-2-ylalkylacetamide, One-pot synthesis",

author = "Li, {Jia Ming} and Wang, {Zhi Yong} and Lei Zeng and Zhou, {Ming Ming}",

year = "2006",

month = jul,

language = "English",

volume = "26",

pages = "971--974",

journal = "Chinese Journal of Organic Chemistry",

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T1 - One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide

AU - Li, Jia Ming

AU - Wang, Zhi Yong

AU - Zeng, Lei

AU - Zhou, Ming Ming

PY - 2006/7

Y1 - 2006/7

N2 - One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide was realized by the reaction of 5-amino-2, 2-dimethyl-1,3-dioxane with acetic anhydride in high regioselectivity and yield with easiness for operation under mild condition. The structures of the products were identified with FTIR, 1H NMR, 13C NMR and HRMS spectra. Compound 4, which should be a potential inhibitor of HIV-1 Tat/PCAF BRD association, can be synthesized from N-3-(1,3-dihydroxyprop-2-yl)propylacetamide easily.

AB - One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide was realized by the reaction of 5-amino-2, 2-dimethyl-1,3-dioxane with acetic anhydride in high regioselectivity and yield with easiness for operation under mild condition. The structures of the products were identified with FTIR, 1H NMR, 13C NMR and HRMS spectra. Compound 4, which should be a potential inhibitor of HIV-1 Tat/PCAF BRD association, can be synthesized from N-3-(1,3-dihydroxyprop-2-yl)propylacetamide easily.

KW - Acetic anhydride

KW - Highly selective acylation

KW - N-1,3-dihydroxyprop-2-ylalkylacetamide

KW - One-pot synthesis

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M3 - Article

AN - SCOPUS:33748036700

SN - 0253-2786

VL - 26

SP - 971

EP - 974

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 7

ER -

One-pot synthesis of N-1,3-dihydroxyprop-2-ylalkylacetamide

Abstract

Keywords

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