One-pot, direct incorporation of [11C]CO2 into carbamates

Jacob M. Hooker; Achim T. Reibel; Sidney M. Hill; Michael J. Schueller; Joanna S. Fowler

doi:10.1002/anie.200900112

One-pot, direct incorporation of [¹¹C]CO₂ into carbamates

Jacob M. Hooker
, Achim T. Reibel
, Sidney M. Hill
, Michael J. Schueller
, Joanna S. Fowler

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of ¹¹CO₂ with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of ¹¹C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

Original language	English
Pages (from-to)	3482-3485
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	19
DOIs	https://doi.org/10.1002/anie.200900112
State	Published - 27 Apr 2009

Keywords

Carbamates
Carbon-11
Isotopic labeling
Positron emission tomography
Radiochemistry

Access to Document

10.1002/anie.200900112

Cite this

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title = "One-pot, direct incorporation of [11C]CO2 into carbamates",

abstract = "Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 \% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.",

keywords = "Carbamates, Carbon-11, Isotopic labeling, Positron emission tomography, Radiochemistry",

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AU - Hooker, Jacob M.

AU - Reibel, Achim T.

AU - Hill, Sidney M.

AU - Schueller, Michael J.

AU - Fowler, Joanna S.

PY - 2009/4/27

Y1 - 2009/4/27

N2 - Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

AB - Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

KW - Carbamates

KW - Carbon-11

KW - Isotopic labeling

KW - Positron emission tomography

KW - Radiochemistry

UR - https://www.scopus.com/pages/publications/70349974774

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JF - Angewandte Chemie - International Edition

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