One-pot, direct incorporation of [11C]CO2 into carbamates

Jacob M. Hooker; Achim T. Reibel; Sidney M. Hill; Michael J. Schueller; Joanna S. Fowler

doi:10.1002/anie.200900112

One-pot, direct incorporation of [¹¹C]CO₂ into carbamates

Jacob M. Hooker, Achim T. Reibel, Sidney M. Hill, Michael J. Schueller, Joanna S. Fowler

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of ¹¹CO₂ with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of ¹¹C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

Original language	English
Pages (from-to)	3482-3485
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	19
DOIs	https://doi.org/10.1002/anie.200900112
State	Published - 27 Apr 2009

Keywords

Carbamates
Carbon-11
Isotopic labeling
Positron emission tomography
Radiochemistry

Access to Document

10.1002/anie.200900112

Cite this

@article{c459bf4e26a5487f97fd7ca2d3c51567,

title = "One-pot, direct incorporation of [11C]CO2 into carbamates",

abstract = "Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.",

keywords = "Carbamates, Carbon-11, Isotopic labeling, Positron emission tomography, Radiochemistry",

author = "Hooker, {Jacob M.} and Reibel, {Achim T.} and Hill, {Sidney M.} and Schueller, {Michael J.} and Fowler, {Joanna S.}",

year = "2009",

month = apr,

day = "27",

doi = "10.1002/anie.200900112",

language = "English",

volume = "48",

pages = "3482--3485",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "19",

}

TY - JOUR

T1 - One-pot, direct incorporation of [11C]CO2 into carbamates

AU - Hooker, Jacob M.

AU - Reibel, Achim T.

AU - Hill, Sidney M.

AU - Schueller, Michael J.

AU - Fowler, Joanna S.

PY - 2009/4/27

Y1 - 2009/4/27

N2 - Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

AB - Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

KW - Carbamates

KW - Carbon-11

KW - Isotopic labeling

KW - Positron emission tomography

KW - Radiochemistry

UR - http://www.scopus.com/inward/record.url?scp=70349974774&partnerID=8YFLogxK

U2 - 10.1002/anie.200900112

DO - 10.1002/anie.200900112

M3 - Article

C2 - 19350593

AN - SCOPUS:70349974774

SN - 1433-7851

VL - 48

SP - 3482

EP - 3485

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19