One-pot, direct incorporation of [11C]CO2 into carbamates

Jacob M. Hooker, Achim T. Reibel, Sidney M. Hill, Michael J. Schueller, Joanna S. Fowler

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75°C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

Original languageEnglish
Pages (from-to)3482-3485
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number19
StatePublished - 27 Apr 2009


  • Carbamates
  • Carbon-11
  • Isotopic labeling
  • Positron emission tomography
  • Radiochemistry


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