One new cycloartane triterpene glycoside from Beesia calthaefolia

Jin Yuan Zhao; Li Hua Mu; Xian Zhe Dong; Yuan Hu; Ping Liu

doi:10.1080/14786419.2015.1058791

One new cycloartane triterpene glycoside from Beesia calthaefolia

Jin Yuan Zhao, Li Hua Mu, Xian Zhe Dong, Yuan Hu, Ping Liu

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

One new cycloartane triterpene glycoside (1) was isolated from the whole plant of Beesia calthaefolia. Its structure was elucidated on the basis of extensive spectroscopic data analysis. Its inhibitory effect was measured by the classical pathway of the complement system, and compared with those of known related cycloartane glycosides 2 and 3, previously isolated by us from the same plant. Compounds 1 and 2 exhibited inhibitory activity of complement system with IC₅₀of 395.3 and 214 μM, respectively. The results suggested that OH at C-12, C-18 and C-15 along with the polarity could affect the inhibitory activity.

Original language	English
Pages (from-to)	316-321
Number of pages	6
Journal	Natural Product Research
Volume	30
Issue number	3
DOIs	https://doi.org/10.1080/14786419.2015.1058791
State	Published - 2016
Externally published	Yes

Keywords

Beesia calthaefolia
classical pathway
complement system
cycloartane triterpene glycoside

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10.1080/14786419.2015.1058791

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title = "One new cycloartane triterpene glycoside from Beesia calthaefolia",

abstract = "One new cycloartane triterpene glycoside (1) was isolated from the whole plant of Beesia calthaefolia. Its structure was elucidated on the basis of extensive spectroscopic data analysis. Its inhibitory effect was measured by the classical pathway of the complement system, and compared with those of known related cycloartane glycosides 2 and 3, previously isolated by us from the same plant. Compounds 1 and 2 exhibited inhibitory activity of complement system with IC50of 395.3 and 214 μM, respectively. The results suggested that OH at C-12, C-18 and C-15 along with the polarity could affect the inhibitory activity.",

keywords = "Beesia calthaefolia, classical pathway, complement system, cycloartane triterpene glycoside",

author = "Zhao, {Jin Yuan} and Mu, {Li Hua} and Dong, {Xian Zhe} and Yuan Hu and Ping Liu",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor & Francis.",

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T1 - One new cycloartane triterpene glycoside from Beesia calthaefolia

AU - Zhao, Jin Yuan

AU - Mu, Li Hua

AU - Dong, Xian Zhe

AU - Hu, Yuan

AU - Liu, Ping

PY - 2016

Y1 - 2016

N2 - One new cycloartane triterpene glycoside (1) was isolated from the whole plant of Beesia calthaefolia. Its structure was elucidated on the basis of extensive spectroscopic data analysis. Its inhibitory effect was measured by the classical pathway of the complement system, and compared with those of known related cycloartane glycosides 2 and 3, previously isolated by us from the same plant. Compounds 1 and 2 exhibited inhibitory activity of complement system with IC50of 395.3 and 214 μM, respectively. The results suggested that OH at C-12, C-18 and C-15 along with the polarity could affect the inhibitory activity.

AB - One new cycloartane triterpene glycoside (1) was isolated from the whole plant of Beesia calthaefolia. Its structure was elucidated on the basis of extensive spectroscopic data analysis. Its inhibitory effect was measured by the classical pathway of the complement system, and compared with those of known related cycloartane glycosides 2 and 3, previously isolated by us from the same plant. Compounds 1 and 2 exhibited inhibitory activity of complement system with IC50of 395.3 and 214 μM, respectively. The results suggested that OH at C-12, C-18 and C-15 along with the polarity could affect the inhibitory activity.

KW - Beesia calthaefolia

KW - classical pathway

KW - complement system

KW - cycloartane triterpene glycoside

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One new cycloartane triterpene glycoside from Beesia calthaefolia

Abstract

Keywords

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