One new cycloartane triterpene glycoside from Beesia calthaefolia

Jin Yuan Zhao, Li Hua Mu, Xian Zhe Dong, Yuan Hu, Ping Liu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

One new cycloartane triterpene glycoside (1) was isolated from the whole plant of Beesia calthaefolia. Its structure was elucidated on the basis of extensive spectroscopic data analysis. Its inhibitory effect was measured by the classical pathway of the complement system, and compared with those of known related cycloartane glycosides 2 and 3, previously isolated by us from the same plant. Compounds 1 and 2 exhibited inhibitory activity of complement system with IC50of 395.3 and 214 μM, respectively. The results suggested that OH at C-12, C-18 and C-15 along with the polarity could affect the inhibitory activity.

Original languageEnglish
Pages (from-to)316-321
Number of pages6
JournalNatural Product Research
Volume30
Issue number3
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Beesia calthaefolia
  • classical pathway
  • complement system
  • cycloartane triterpene glycoside

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