Oncolytic Newcastle disease virus for cancer therapy: Old challenges and new directions

Dmitriy Zamarin, Peter Palese

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations

Abstract

Newcastle disease virus (NDV) is an avian paramyxovirus, which has been demonstrated to possess significant oncolytic activity against mammalian cancers. This review summarizes the research leading to the elucidation of the mechanisms of NDV-mediated oncolysis, as well as the development of novel oncolytic agents through the use of genetic engineering. Clinical trials utilizing NDV strains and NDV-based autologous tumor cell vaccines will expand our knowledge of these novel anticancer strategies and will ultimately result in the successful use of the virus in the clinical setting.

Original languageEnglish
Pages (from-to)347-367
Number of pages21
JournalFuture Microbiology
Volume7
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • NDV
  • apoptosis
  • cancer
  • immunotherapy
  • interferon
  • oncolytic

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