Oncocytoid Variant of High-Grade Salivary Duct Carcinoma: A Potential Diagnostic Pitfall. A Report on Two Patients

Ammar Matloob, John E. Beute, Sunder Gidumal, Mohamed Rabie, Azita S. Khorsandi, Mark L. Urken, Raymond L. Chai, Margaret Brandwein-Weber

Research output: Contribution to journalArticlepeer-review

Abstract

Salivary duct carcinoma (SDC) is an uncommon and aggressive salivary malignancy. The oncocytoid variant of salivary duct carcinoma (OSDC) has only been reported in the English literature once before. Here we detail two new patients. A 71-year-old female presented with a painless enlarging left parotid mass. Imaging and fine-needle aspiration were nondiagnostic. The second patient, a 79-year-old male, presented with painless swelling in the right cheek. Imaging was nondiagnostic. Both patients underwent surgical resection. Histopathology revealed bland yet infiltrative OSDC in both cases. These tumors were AR+ (androgen receptor) by immunohistochemistry. Potential difficulty exists in distinguishing the oncocytoid variant of SDC, a rare and relatively bland tumor, from oncocytoma, a more commonly encountered entity. AR expression can aid in the correct diagnosis.

Original languageEnglish
JournalHead and Neck Pathology
DOIs
StateAccepted/In press - 2022

Keywords

  • Biopsy, fine-needle
  • Carcinoma, ductal
  • Carcinoma, mucoepidermoid
  • Diagnosis, differential
  • Immunohistochemistry
  • Parotid gland
  • Receptors, androgen

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