Onabotulinumtoxin A (BOTOX®) for ProphylaCTIC Treatment of Pediatric Migraine: A Retrospective Longitudinal Analysis

Shalini Shah, Michael David Calderon, Wei Der Wu, Jihan Grant, Joseph Rinehart

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: The use of onabotulinumtoxin A in the pediatric population has not been evaluated for chronic migraine in a longitudinal study. This retrospective study sought to determine the efficacy and safety of onabotulinumtoxin A in prophylactic treatment of chronic migraine in the pediatric population. Methods: The authors retrospectively evaluated pediatric patients who had been treated with onabotulinumtoxin A in the outpatient pain clinic for chronic migraine. Demographic data and pre- and posttreatment migraine days (frequency), pain scores (intensity), and duration of migraine episodes were collected from patient records. Results: Ten patients were included. Median pretreatment to posttreatment headache frequency was 15.5 [8, 29.5] to 4 [2, 10] days/month (P <.0001), durations were 8 [0, 24] to 1 [0, 7] hours (P =.025), and intensity was 6 [4, 8] to 4 [2, 5] (P =.0063). No serious adverse events were reported. Conclusions: This review over a 5-year longitudinal period demonstrates statistically significant improvement from baseline.

Original languageEnglish
Pages (from-to)580-586
Number of pages7
JournalJournal of Child Neurology
Issue number9
StatePublished - 1 Aug 2018
Externally publishedYes


  • children
  • chronic migraine
  • migraine prophylaxis
  • onabotulinumtoxin A
  • pediatric migraine


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