On the origins of clinical drug resistance

J. P. O'Brien; C. Cordon-Cardo

On the origins of clinical drug resistance

J. P. O'Brien
, C. Cordon-Cardo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Recent progress in understanding the clinical importance of certain laboratory models of drug resistance is cause for clinical oncologists to rethink some of the current concepts used in developing chemotherapy programs. The following discussion will reexamine a popular model of resistance development and highlight certain insights gained from clinical and laboratory studies of multidrug resistance. Such insights both challenge traditional concepts of cancer treatment and suggest new therapeutic approaches that would otherwise not have been apparent.

Original language	English
Pages (from-to)	227-233
Number of pages	7
Journal	Seminars in Cancer Biology
Volume	2
Issue number	4
State	Published - Aug 1991
Externally published	Yes

Keywords

Cancer chemotherapy
Multidrug resistance

Cite this

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title = "On the origins of clinical drug resistance",

abstract = "Recent progress in understanding the clinical importance of certain laboratory models of drug resistance is cause for clinical oncologists to rethink some of the current concepts used in developing chemotherapy programs. The following discussion will reexamine a popular model of resistance development and highlight certain insights gained from clinical and laboratory studies of multidrug resistance. Such insights both challenge traditional concepts of cancer treatment and suggest new therapeutic approaches that would otherwise not have been apparent.",

keywords = "Cancer chemotherapy, Multidrug resistance",

author = "O'Brien, \{J. P.\} and C. Cordon-Cardo",

year = "1991",

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pages = "227--233",

journal = "Seminars in Cancer Biology",

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T1 - On the origins of clinical drug resistance

AU - O'Brien, J. P.

AU - Cordon-Cardo, C.

PY - 1991/8

Y1 - 1991/8

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AB - Recent progress in understanding the clinical importance of certain laboratory models of drug resistance is cause for clinical oncologists to rethink some of the current concepts used in developing chemotherapy programs. The following discussion will reexamine a popular model of resistance development and highlight certain insights gained from clinical and laboratory studies of multidrug resistance. Such insights both challenge traditional concepts of cancer treatment and suggest new therapeutic approaches that would otherwise not have been apparent.

KW - Cancer chemotherapy

KW - Multidrug resistance

UR - https://www.scopus.com/pages/publications/0026209644

M3 - Article

C2 - 1680494

AN - SCOPUS:0026209644

SN - 1044-579X

VL - 2

SP - 227

EP - 233

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 4

ER -

On the origins of clinical drug resistance

Abstract

Keywords

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Cite this