On regulation of phagosome maturation and antigen presentation

J. Magarian Blander, Ruslan Medzhitov

Research output: Contribution to journalArticlepeer-review

249 Scopus citations


Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self-non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. An inducible mode of phagosome maturation triggered by these receptors ensures the selection of microbial antigens for presentation by major histocompatibility class II molecules during the simultaneous phagocytosis of self and non-self.

Original languageEnglish
Pages (from-to)1029-1035
Number of pages7
JournalNature Immunology
Issue number10
StatePublished - Oct 2006


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