Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy

Hiroyuki Inoue; Tsutomu Kawaguchi; Hisashi Ikoma; Ryo Morimura; Yusuke Yamamoto; Toshiya Ochiai; Hiroki Shimizu; Tomohiro Arita; Hirotaka Konishi; Atsushi Shiozaki; Yoshiaki Kuriu; Takeshi Kubota; Hitoshi Fujiwara; Kazuma Okamoto; Hideo Takahashi; Kazuaki Takabe; Allan Tsung; Eigo Otsuji

doi:10.1002/jso.26575

Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy

Hiroyuki Inoue, Tsutomu Kawaguchi, Hisashi Ikoma, Ryo Morimura, Yusuke Yamamoto, Toshiya Ochiai, Hiroki Shimizu, Tomohiro Arita, Hirotaka Konishi, Atsushi Shiozaki, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Hideo Takahashi, Kazuaki Takabe, Allan Tsung, Eigo Otsuji

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Oligometastasis, the presence of a small number of resectable metastatic tumors, usually has favorable outcomes. Here we examined whether the novel oligometastatic score (OLGS), which divides the number of colorectal liver metastases (CRLMs) by the time from colorectal resection to liver recurrence, better predicts CRLM patient survival than the commonly used clinical risk score. Methods: A total of 143 patients who underwent curative hepatectomy for CRLMs between 2007 and 2018 were analyzed. We investigated their clinical characteristics and outcomes using OLGS. Results: Of the 143 CRLM patients, 70 had synchronous CRLMs and 73 had metachronous CRLMs. Patients with metachronous CRLMs were divided into OLGS-low (n = 59) and OLGS-high (n = 14) subgroups. The 5-year overall survival (OS) rates after hepatectomy differed significantly between the subgroups (p <.001). In the multivariate Cox model, a high OLGS was an independent predictor of 5-year OS (p <.001), and the hazard ratio (HR) of the OLGS-high group (HR = 7.171) was higher than that of the high clinical risk score group (HR = 4.337). Conclusion: The OLGS, a simple and handy scoring system, better predicts the 5-year OS of patients with CRLMs after hepatectomy and warrants prospective validation.

Original language	English
Pages (from-to)	791-800
Number of pages	10
Journal	Journal of Surgical Oncology
Volume	124
Issue number	5
DOIs	https://doi.org/10.1002/jso.26575
State	Published - 1 Oct 2021
Externally published	Yes

Keywords

clinical outcome
colorectal cancer
liver metastasis
oligometastasis

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10.1002/jso.26575

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Inoue, H., Kawaguchi, T., Ikoma, H., Morimura, R., Yamamoto, Y., Ochiai, T., Shimizu, H., Arita, T., Konishi, H., Shiozaki, A., Kuriu, Y., Kubota, T., Fujiwara, H., Okamoto, K., Takahashi, H., Takabe, K., Tsung, A., & Otsuji, E. (2021). Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy. Journal of Surgical Oncology, 124(5), 791-800. https://doi.org/10.1002/jso.26575

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title = "Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy",

abstract = "Background: Oligometastasis, the presence of a small number of resectable metastatic tumors, usually has favorable outcomes. Here we examined whether the novel oligometastatic score (OLGS), which divides the number of colorectal liver metastases (CRLMs) by the time from colorectal resection to liver recurrence, better predicts CRLM patient survival than the commonly used clinical risk score. Methods: A total of 143 patients who underwent curative hepatectomy for CRLMs between 2007 and 2018 were analyzed. We investigated their clinical characteristics and outcomes using OLGS. Results: Of the 143 CRLM patients, 70 had synchronous CRLMs and 73 had metachronous CRLMs. Patients with metachronous CRLMs were divided into OLGS-low (n = 59) and OLGS-high (n = 14) subgroups. The 5-year overall survival (OS) rates after hepatectomy differed significantly between the subgroups (p <.001). In the multivariate Cox model, a high OLGS was an independent predictor of 5-year OS (p <.001), and the hazard ratio (HR) of the OLGS-high group (HR = 7.171) was higher than that of the high clinical risk score group (HR = 4.337). Conclusion: The OLGS, a simple and handy scoring system, better predicts the 5-year OS of patients with CRLMs after hepatectomy and warrants prospective validation.",

keywords = "clinical outcome, colorectal cancer, liver metastasis, oligometastasis",

author = "Hiroyuki Inoue and Tsutomu Kawaguchi and Hisashi Ikoma and Ryo Morimura and Yusuke Yamamoto and Toshiya Ochiai and Hiroki Shimizu and Tomohiro Arita and Hirotaka Konishi and Atsushi Shiozaki and Yoshiaki Kuriu and Takeshi Kubota and Hitoshi Fujiwara and Kazuma Okamoto and Hideo Takahashi and Kazuaki Takabe and Allan Tsung and Eigo Otsuji",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

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doi = "10.1002/jso.26575",

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Inoue, H, Kawaguchi, T, Ikoma, H, Morimura, R, Yamamoto, Y, Ochiai, T, Shimizu, H, Arita, T, Konishi, H, Shiozaki, A, Kuriu, Y, Kubota, T, Fujiwara, H, Okamoto, K, Takahashi, H, Takabe, K, Tsung, A & Otsuji, E 2021, 'Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy', Journal of Surgical Oncology, vol. 124, no. 5, pp. 791-800. https://doi.org/10.1002/jso.26575

TY - JOUR

T1 - Oligometastasis scoring system for predicting survival of patients with colorectal liver metastasis after hepatectomy

AU - Inoue, Hiroyuki

AU - Kawaguchi, Tsutomu

AU - Ikoma, Hisashi

AU - Morimura, Ryo

AU - Yamamoto, Yusuke

AU - Ochiai, Toshiya

AU - Shimizu, Hiroki

AU - Arita, Tomohiro

AU - Konishi, Hirotaka

AU - Shiozaki, Atsushi

AU - Kuriu, Yoshiaki

AU - Kubota, Takeshi

AU - Fujiwara, Hitoshi

AU - Okamoto, Kazuma

AU - Takahashi, Hideo

AU - Takabe, Kazuaki

AU - Tsung, Allan

AU - Otsuji, Eigo

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Background: Oligometastasis, the presence of a small number of resectable metastatic tumors, usually has favorable outcomes. Here we examined whether the novel oligometastatic score (OLGS), which divides the number of colorectal liver metastases (CRLMs) by the time from colorectal resection to liver recurrence, better predicts CRLM patient survival than the commonly used clinical risk score. Methods: A total of 143 patients who underwent curative hepatectomy for CRLMs between 2007 and 2018 were analyzed. We investigated their clinical characteristics and outcomes using OLGS. Results: Of the 143 CRLM patients, 70 had synchronous CRLMs and 73 had metachronous CRLMs. Patients with metachronous CRLMs were divided into OLGS-low (n = 59) and OLGS-high (n = 14) subgroups. The 5-year overall survival (OS) rates after hepatectomy differed significantly between the subgroups (p <.001). In the multivariate Cox model, a high OLGS was an independent predictor of 5-year OS (p <.001), and the hazard ratio (HR) of the OLGS-high group (HR = 7.171) was higher than that of the high clinical risk score group (HR = 4.337). Conclusion: The OLGS, a simple and handy scoring system, better predicts the 5-year OS of patients with CRLMs after hepatectomy and warrants prospective validation.

AB - Background: Oligometastasis, the presence of a small number of resectable metastatic tumors, usually has favorable outcomes. Here we examined whether the novel oligometastatic score (OLGS), which divides the number of colorectal liver metastases (CRLMs) by the time from colorectal resection to liver recurrence, better predicts CRLM patient survival than the commonly used clinical risk score. Methods: A total of 143 patients who underwent curative hepatectomy for CRLMs between 2007 and 2018 were analyzed. We investigated their clinical characteristics and outcomes using OLGS. Results: Of the 143 CRLM patients, 70 had synchronous CRLMs and 73 had metachronous CRLMs. Patients with metachronous CRLMs were divided into OLGS-low (n = 59) and OLGS-high (n = 14) subgroups. The 5-year overall survival (OS) rates after hepatectomy differed significantly between the subgroups (p <.001). In the multivariate Cox model, a high OLGS was an independent predictor of 5-year OS (p <.001), and the hazard ratio (HR) of the OLGS-high group (HR = 7.171) was higher than that of the high clinical risk score group (HR = 4.337). Conclusion: The OLGS, a simple and handy scoring system, better predicts the 5-year OS of patients with CRLMs after hepatectomy and warrants prospective validation.

KW - clinical outcome

KW - colorectal cancer

KW - liver metastasis

KW - oligometastasis

UR - http://www.scopus.com/inward/record.url?scp=85108902372&partnerID=8YFLogxK

U2 - 10.1002/jso.26575

DO - 10.1002/jso.26575

M3 - Article

C2 - 34196000

AN - SCOPUS:85108902372

SN - 0022-4790

VL - 124

SP - 791

EP - 800

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 5

ER -