TY - JOUR
T1 - OligoMatcher
T2 - Analysis and selection of specific oligonucleotide sequences for gene silencing by antisense or siRNA
AU - Mamidipalli, Sudha Rani
AU - Palakal, Mathew
AU - Li, Shuyu
N1 - Funding Information:
We thank Drs Jude Onyia, Eric Su and Birong Liao for their support and critical review. The research reported in this paper was supported in part by National Science Foundation (NSF) Information Technology Research (ITR) grant number NSF-IIS/ITR 0081944, a National Institutes of Health (NIH) BISTI (Biomedical Information Science and Technology Initiative) grant, and NIH-NIGMS (National Institute of General Medical Sciences) grant number P20 GM66402.
PY - 2006
Y1 - 2006
N2 - OligoMatcher is a web-based tool for analysis and selection of unique oligonucleotide sequences for gene silencing by antisense oligonucleotides (ASOs) or small interfering RNA (siRNA). A specific BLAST® server was built for analysing sequences of ASOs that target pre-mRNA in the cell nucleus. Tissue- and cell-specific expression data of potential cross-reactive genes are integrated in the OligoMatcher program, which allows biologists to select unique oligonucleotide sequences for their target genes in specific experimental systems.
AB - OligoMatcher is a web-based tool for analysis and selection of unique oligonucleotide sequences for gene silencing by antisense oligonucleotides (ASOs) or small interfering RNA (siRNA). A specific BLAST® server was built for analysing sequences of ASOs that target pre-mRNA in the cell nucleus. Tissue- and cell-specific expression data of potential cross-reactive genes are integrated in the OligoMatcher program, which allows biologists to select unique oligonucleotide sequences for their target genes in specific experimental systems.
UR - http://www.scopus.com/inward/record.url?scp=33744907470&partnerID=8YFLogxK
U2 - 10.2165/00822942-200605020-00008
DO - 10.2165/00822942-200605020-00008
M3 - Article
C2 - 16722778
AN - SCOPUS:33744907470
SN - 1175-5636
VL - 5
SP - 121
EP - 124
JO - Applied Bioinformatics
JF - Applied Bioinformatics
IS - 2
ER -