TY - JOUR
T1 - Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals
AU - Sohrabi, Hamid R.
AU - Bates, Kristyn A.
AU - Rodrigues, Mark
AU - Taddei, Kevin
AU - Laws, Simon M.
AU - Lautenschlager, Nicola T.
AU - Dhaliwal, Satvinder S.
AU - Johnston, Amy N.B.
AU - MacKay-Sim, Alan
AU - Gandy, Samuel
AU - Foster, Jonathan K.
AU - Martins, Ralph N.
PY - 2009
Y1 - 2009
N2 - Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.
AB - Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.
KW - Alzheimer's disease
KW - Cognitive decline
KW - Depression symptoms
KW - Olfactory dysfunction
KW - Smell identification
KW - Sniffin' Sticks
KW - Subjective memory complaints
UR - http://www.scopus.com/inward/record.url?scp=67650898564&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-1020
DO - 10.3233/JAD-2009-1020
M3 - Article
C2 - 19494438
AN - SCOPUS:67650898564
SN - 1387-2877
VL - 17
SP - 135
EP - 142
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -