Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety

Enrico Ullmann; George Chrousos; Seth W. Perry; Ma Li Wong; Julio Licinio; Stefan R. Bornstein; Olga Tseilikman; Maria Komelkova; Maxim S. Lapshin; Maryia Vasilyeva; Evgenii Zavjalov; Oleg Shevelev; Nikita Khotskin; Galina Koncevaya; Anna S. Khotskina; Mikhail Moshkin; Olga Cherkasova; Alexey Sarapultsev; Roman Ibragimov; Igor Kritsky; Jörg M. Fegert; Vadim Tseilikman; Rachel Yehuda

doi:10.3390/ijms21207440

Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety

Enrico Ullmann, George Chrousos, Seth W. Perry, Ma Li Wong, Julio Licinio, Stefan R. Bornstein, Olga Tseilikman, Maria Komelkova, Maxim S. Lapshin, Maryia Vasilyeva, Evgenii Zavjalov, Oleg Shevelev, Nikita Khotskin, Galina Koncevaya, Anna S. Khotskina, Mikhail Moshkin, Olga Cherkasova, Alexey Sarapultsev, Roman Ibragimov, Igor KritskyJörg M. Fegert, Vadim Tseilikman, Rachel Yehuda

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13 Scopus citations

Abstract

Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.

Original language	English
Article number	7440
Pages (from-to)	1-16
Number of pages	16
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	20
DOIs	https://doi.org/10.3390/ijms21207440
State	Published - 2 Oct 2020

Keywords

CPTSD
Chronic stress
Glutamate
Striatum

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10.3390/ijms21207440

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Ullmann, E., Chrousos, G., Perry, S. W., Wong, M. L., Licinio, J., Bornstein, S. R., Tseilikman, O., Komelkova, M., Lapshin, M. S., Vasilyeva, M., Zavjalov, E., Shevelev, O., Khotskin, N., Koncevaya, G., Khotskina, A. S., Moshkin, M., Cherkasova, O., Sarapultsev, A., Ibragimov, R., ... Yehuda, R. (2020). Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety. International Journal of Molecular Sciences, 21(20), 1-16. Article 7440. https://doi.org/10.3390/ijms21207440

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title = "Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety",

abstract = "Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.",

keywords = "CPTSD, Chronic stress, Glutamate, Striatum",

author = "Enrico Ullmann and George Chrousos and Perry, \{Seth W.\} and Wong, \{Ma Li\} and Julio Licinio and Bornstein, \{Stefan R.\} and Olga Tseilikman and Maria Komelkova and Lapshin, \{Maxim S.\} and Maryia Vasilyeva and Evgenii Zavjalov and Oleg Shevelev and Nikita Khotskin and Galina Koncevaya and Khotskina, \{Anna S.\} and Mikhail Moshkin and Olga Cherkasova and Alexey Sarapultsev and Roman Ibragimov and Igor Kritsky and Fegert, \{J{\"o}rg M.\} and Vadim Tseilikman and Rachel Yehuda",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = oct,

day = "2",

doi = "10.3390/ijms21207440",

language = "English",

volume = "21",

pages = "1--16",

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Ullmann, E, Chrousos, G, Perry, SW, Wong, ML, Licinio, J, Bornstein, SR, Tseilikman, O, Komelkova, M, Lapshin, MS, Vasilyeva, M, Zavjalov, E, Shevelev, O, Khotskin, N, Koncevaya, G, Khotskina, AS, Moshkin, M, Cherkasova, O, Sarapultsev, A, Ibragimov, R, Kritsky, I, Fegert, JM, Tseilikman, V & Yehuda, R 2020, 'Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety', International Journal of Molecular Sciences, vol. 21, no. 20, 7440, pp. 1-16. https://doi.org/10.3390/ijms21207440

TY - JOUR

T1 - Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety

AU - Ullmann, Enrico

AU - Chrousos, George

AU - Perry, Seth W.

AU - Wong, Ma Li

AU - Licinio, Julio

AU - Bornstein, Stefan R.

AU - Tseilikman, Olga

AU - Komelkova, Maria

AU - Lapshin, Maxim S.

AU - Vasilyeva, Maryia

AU - Zavjalov, Evgenii

AU - Shevelev, Oleg

AU - Khotskin, Nikita

AU - Koncevaya, Galina

AU - Khotskina, Anna S.

AU - Moshkin, Mikhail

AU - Cherkasova, Olga

AU - Sarapultsev, Alexey

AU - Ibragimov, Roman

AU - Kritsky, Igor

AU - Fegert, Jörg M.

AU - Tseilikman, Vadim

AU - Yehuda, Rachel

PY - 2020/10/2

Y1 - 2020/10/2

N2 - Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.

AB - Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.

KW - CPTSD

KW - Chronic stress

KW - Glutamate

KW - Striatum

UR - https://www.scopus.com/pages/publications/85092372750

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DO - 10.3390/ijms21207440

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C2 - 33050201

AN - SCOPUS:85092372750

SN - 1661-6596

VL - 21

SP - 1

EP - 16

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 20

M1 - 7440

ER -

Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety

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Keywords

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