Of form and function: Early cardiac morphogenesis across classical and emerging model systems

Bhavana Shewale, Nicole Dubois

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The heart is the earliest organ to develop during embryogenesis and is remarkable in its ability to function efficiently as it is being sculpted. Cardiac heart defects account for a high burden of childhood developmental disorders with many remaining poorly understood mechanistically. Decades of work across a multitude of model organisms has informed our understanding of early cardiac differentiation and morphogenesis and has simultaneously opened new and unanswered questions. Here we have synthesized current knowledge in the field and reviewed recent developments in the realm of imaging, bioengineering and genetic technology and ex vivo cardiac modeling that may be deployed to generate more holistic models of early cardiac morphogenesis, and by extension, new platforms to study congenital heart defects.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume118
DOIs
StatePublished - Oct 2021

Keywords

  • Cardiac organoids
  • Morphogenesis
  • Pluripotent stem cells
  • Progenitor specification

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