Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer

S. Lehrer; H. K. Song; E. Levine; J. Dalton; P. Savoretti; B. Schachter; M. Sanchez; S. N. Thung

doi:10.1016/0140-6736(90)90410-7

Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer

S. Lehrer, H. K. Song, E. Levine, J. Dalton, P. Savoretti, B. Schachter, M. Sanchez, S. N. Thung

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Abstract

To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.

Original language	English
Pages (from-to)	622-624
Number of pages	3
Journal	The Lancet
Volume	335
Issue number	8690
DOIs	https://doi.org/10.1016/0140-6736(90)90410-7
State	Published - 17 Mar 1990

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title = "Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer",

abstract = "To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.",

author = "S. Lehrer and Song, {H. K.} and E. Levine and J. Dalton and P. Savoretti and B. Schachter and M. Sanchez and Thung, {S. N.}",

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AU - Lehrer, S.

AU - Song, H. K.

AU - Levine, E.

AU - Dalton, J.

AU - Savoretti, P.

AU - Schachter, B.

AU - Sanchez, M.

AU - Thung, S. N.

N1 - Funding Information: The study was funded in part by NIH OlAl.

PY - 1990/3/17

Y1 - 1990/3/17

N2 - To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.

AB - To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.

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VL - 335

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JO - The Lancet

JF - The Lancet

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Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer

Abstract

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