Ocular Tumors

N. V. Laver, K. Sitko, J. Duker, N. A. Farhat

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

Retinoblastoma and uveal melanoma are the two most common primary intraocular maLignancies. Both remain potentially fatal diseases despite marked advancements in their diagnosis, treatment, and, in the case of retinoblastoma, prognosis. A large amount of research into the pathobiology of retinoblastoma with the use of animal models has resulted in the isolation of the causative gene (Rb), one of the first tumor suppressor genes identified having a direct role in many other tumors. The concepts elucidated through work on Rb have proven universally relevant in our understanding of cancer pathobiology. In uveal melanoma, much progress has been made in diagnosis, cytogenetic stratification, and earLier local treatment. However, survival rates have remained constant over the past 50 years. New chemotherapeutic systemic therapies to treat metastatic disease will in the future reduce the mortaLity rates. The objective of this article is to review the cLinical findings, histopathology, molecular genetics, and animal models.

Original languageEnglish
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages2179-2200
Number of pages22
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Cancer
  • Chemotherapy
  • Choroid
  • Cytogenetics
  • Enucleation
  • Eye
  • GNAQ mutation
  • Hereditary
  • Histopathology
  • Leukocoria
  • Melanoma
  • Molecular classification
  • Molecular genetics
  • Monosomy 3
  • Optic nerve
  • Pathology
  • Plaque radiotherapy
  • Rb gene
  • Retina
  • Retinoblastoma
  • Sporadic
  • Tumor
  • Tumor animal models
  • Tumor cell Lines
  • Ultrasonography (B-scan)

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