Ocular pulse amplitude in normal tension and primary open angle glaucoma

Ingeborg Stalmans, Alon Harris, Veerle Vanbellinghen, Thierry Zeyen, Brent Siesky

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


PURPOSE: (1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open angle and normal tension glaucoma (NTG). METHODS: Patients with NTG (n=28), primary open angle glaucoma (POAG) (n=19), and age-matched healthy controls (n=22) underwent 2 consecutive Goldmann and dynamic contour tonometry measurements within 1 month. Central corneal thickness was also measured. A regression model was applied to compare OPA between the diagnostic groups. RESULTS: OPA increased with rising IOP (slope 0.026/0.033 and P=0.002/<0.0001 for Goldmann/Dynamic tonometry), whereas corneal thickness did not influence pulse amplitude measurements (slope-0.0017/-0.0013 and P=0.11/0.21 after correction for Goldmann/Dynamic tonometry). In a multivariate model correcting for IOP and corneal thickness, OPA was reduced in patients with NTG (P=0.014/0.017 corrected for Goldmann/Dynamic tonometry) or POAG (P=0.015/0.014). CONCLUSIONS: OPA is reduced in normal tension and POAG patients compared with healthy controls. OPA is influenced by IOP, but not by corneal thickness.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalJournal of Glaucoma
Issue number5
StatePublished - Aug 2008
Externally publishedYes


  • Corneal thickness
  • Dynamic contour tonometer
  • Glaucoma
  • Goldmann
  • Ocular pulse amplitude
  • Pachymetry


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