TY - JOUR
T1 - Ocular perfusion pressure in glaucoma
AU - Costa, Vital P.
AU - Harris, Alon
AU - Anderson, Douglas
AU - Stodtmeister, Richard
AU - Cremasco, Fernanda
AU - Kergoat, Helene
AU - Lovasik, John
AU - Stalmans, Ingborg
AU - Zeitz, Oliver
AU - Lanzl, Ines
AU - Gugleta, Konstantin
AU - Schmetterer, Leopold
PY - 2014/6
Y1 - 2014/6
N2 - This review article discusses the relationship between ocular perfusion pressure and glaucoma, including its definition, factors that influence its calculation and epidemiological studies investigating the influence of ocular perfusion pressure on the prevalence, incidence and progression of glaucoma. We also list the possible mechanisms behind this association, and discuss whether it is secondary to changes in intraocular pressure, blood pressure or both. Finally, we describe the circadian variation of ocular perfusion pressure and the effects of systemic and topical medications on it. We believe that the balance between IOP and BP, influenced by the autoregulatory capacity of the eye, is part of what determines whether an individual will develop optic nerve damage. However, prospective, longitudinal studies are needed to better define the role of ocular perfusion pressure in the development and progression of glaucoma.
AB - This review article discusses the relationship between ocular perfusion pressure and glaucoma, including its definition, factors that influence its calculation and epidemiological studies investigating the influence of ocular perfusion pressure on the prevalence, incidence and progression of glaucoma. We also list the possible mechanisms behind this association, and discuss whether it is secondary to changes in intraocular pressure, blood pressure or both. Finally, we describe the circadian variation of ocular perfusion pressure and the effects of systemic and topical medications on it. We believe that the balance between IOP and BP, influenced by the autoregulatory capacity of the eye, is part of what determines whether an individual will develop optic nerve damage. However, prospective, longitudinal studies are needed to better define the role of ocular perfusion pressure in the development and progression of glaucoma.
KW - blood pressure
KW - glaucoma risk factors
KW - ocular perfusion pressure
KW - optic nerve blood flow
UR - http://www.scopus.com/inward/record.url?scp=84901373070&partnerID=8YFLogxK
U2 - 10.1111/aos.12298
DO - 10.1111/aos.12298
M3 - Review article
C2 - 24238296
AN - SCOPUS:84901373070
SN - 1755-375X
VL - 92
SP - e252-e266
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 4
ER -