Ocular dyskinesias in patients with Parkinson's disease treated with levodopa

Natsue Shimizu, Bernard Cohen, Stanley P. Bala, Marina Mendoza, Melvin D. Yahr

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Abnormal involuntary eye movements were found in 8 of 27 patients with Parkinson's disease who were receiving levodopa and dopa decarboxylase inhibitors. The dyskinetic eye movements were smooth, slow, “to‐and‐fro” ocular deviations of large amplitude. They were suppressed by visual fixation and were prominent only in darkness or behind closed lids when patients were alert. They generally appeared in conjunction with involuntary body and limb movements but could occur alone. Many of the patients with ocular dyskinesias had prominent “on‐off” responses to levodopa. Ocular dyskinesias were present in 8 of 10 patients with bodily dyskinesias. This suggests that if recording conditions are appropriate, these eye movements will commonly be found in patients with Parkinson's disease who develop abnormal involuntary bodily movements while they are receiving levodopa therapy.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalAnnals of Neurology
Volume1
Issue number2
DOIs
StatePublished - Feb 1977

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