Occupational exposure to polychlorinated biphenyls and risk of cutaneous melanoma: A meta-analysis

Paolo Boffetta, Simona Catalani, Cesare Tomasi, Enrico Pira, Pietro Apostoli

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The aim of this study was to carry out a meta-analysis of studies on exposure to polychlorinated biphenyls (PCBs) and the risk of malignant melanoma (MM). We searched Scopus, PubMed, and reference lists; among 807 potentially relevant articles, we selected those based on 12 populations. Data were extracted according to a standardized form; the Newcastle-Ottawa Scale was used to assess study quality. Meta-analyses were carried out according to fixed-effect and random-effects models. The fixed-effect summary relative risk (RR) for MM was 0.91 [95% confidence interval (CI): 0.82-1.00]; the random-effects summary RR was 1.05 (95% CI: 0.78-1.32). The random-effects summary RR from eight occupational cohorts was 1.13 (95% CI: 0.91-1.35) and that from four community-based studies was 0.84 (95% CI: 0.36-1.31). The quality of the studies and the methods for PCB exposure assessment did not influence the RR. These results do not support the hypothesis of an association between PCB exposure and the risk of MM.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalEuropean Journal of Cancer Prevention
Issue number1
StatePublished - 1 Jan 2018


  • malignant melanoma
  • meta-analysis
  • polychlorinated biphenyls


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