Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study

Richard F. Seegal; Kenneth L. Marek; John P. Seibyl; Danna L. Jennings; Eric S. Molho; Donald S. Higgins; Stewart A. Factor; Edward F. Fitzgerald; Elaine A. Hills; Susan A. Korrick; Mary S. Wolff; Richard F. Haase; Andrew C. Todd; Patrick Parsons; Robert J. McCaffrey

doi:10.1016/j.nbd.2010.01.009

Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study

Richard F. Seegal, Kenneth L. Marek, John P. Seibyl, Danna L. Jennings, Eric S. Molho, Donald S. Higgins, Stewart A. Factor, Edward F. Fitzgerald, Elaine A. Hills, Susan A. Korrick, Mary S. Wolff, Richard F. Haase, Andrew C. Todd, Patrick Parsons, Robert J. McCaffrey

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47 Scopus citations

Abstract

We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [¹²³I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.

Original language	English
Pages (from-to)	219-225
Number of pages	7
Journal	Neurobiology of Disease
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.nbd.2010.01.009
State	Published - May 2010

Keywords

Adults
Occupational exposure
Polychlorinated biphenyls (PCBs)
Striatal dopamine transporter (DAT)
β-CIT imaging

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Seegal, R. F., Marek, K. L., Seibyl, J. P., Jennings, D. L., Molho, E. S., Higgins, D. S., Factor, S. A., Fitzgerald, E. F., Hills, E. A., Korrick, S. A., Wolff, M. S., Haase, R. F., Todd, A. C., Parsons, P., & McCaffrey, R. J. (2010). Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study. Neurobiology of Disease, 38(2), 219-225. https://doi.org/10.1016/j.nbd.2010.01.009

@article{b58a0583ebfc46c2a2b98ad617563731,

title = "Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study",

abstract = "We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.",

keywords = "Adults, Occupational exposure, Polychlorinated biphenyls (PCBs), Striatal dopamine transporter (DAT), β-CIT imaging",

author = "Seegal, {Richard F.} and Marek, {Kenneth L.} and Seibyl, {John P.} and Jennings, {Danna L.} and Molho, {Eric S.} and Higgins, {Donald S.} and Factor, {Stewart A.} and Fitzgerald, {Edward F.} and Hills, {Elaine A.} and Korrick, {Susan A.} and Wolff, {Mary S.} and Haase, {Richard F.} and Todd, {Andrew C.} and Patrick Parsons and McCaffrey, {Robert J.}",

note = "Funding Information: This study was supported in part by the United States Army Grant DAMD17-02-1-0173 and NIEHS Grant 1R01ES014675-01 to Richard F. Seegal. ",

year = "2010",

month = may,

doi = "10.1016/j.nbd.2010.01.009",

language = "English",

volume = "38",

pages = "219--225",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press Inc.",

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Seegal, RF, Marek, KL, Seibyl, JP, Jennings, DL, Molho, ES, Higgins, DS, Factor, SA, Fitzgerald, EF, Hills, EA, Korrick, SA, Wolff, MS, Haase, RF, Todd, AC, Parsons, P & McCaffrey, RJ 2010, 'Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study', Neurobiology of Disease, vol. 38, no. 2, pp. 219-225. https://doi.org/10.1016/j.nbd.2010.01.009

TY - JOUR

T1 - Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women

T2 - A β-CIT imaging study

AU - Seegal, Richard F.

AU - Marek, Kenneth L.

AU - Seibyl, John P.

AU - Jennings, Danna L.

AU - Molho, Eric S.

AU - Higgins, Donald S.

AU - Factor, Stewart A.

AU - Fitzgerald, Edward F.

AU - Hills, Elaine A.

AU - Korrick, Susan A.

AU - Wolff, Mary S.

AU - Haase, Richard F.

AU - Todd, Andrew C.

AU - Parsons, Patrick

AU - McCaffrey, Robert J.

N1 - Funding Information: This study was supported in part by the United States Army Grant DAMD17-02-1-0173 and NIEHS Grant 1R01ES014675-01 to Richard F. Seegal.

PY - 2010/5

Y1 - 2010/5

N2 - We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.

AB - We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.

KW - Adults

KW - Occupational exposure

KW - Polychlorinated biphenyls (PCBs)

KW - Striatal dopamine transporter (DAT)

KW - β-CIT imaging

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DO - 10.1016/j.nbd.2010.01.009

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SN - 0969-9961

VL - 38

SP - 219

EP - 225

JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - 2

ER -

Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A β-CIT imaging study

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Keywords

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