TY - JOUR
T1 - Occupational exposure to crystalline silica and risk of lung cancer
T2 - A multicenter case-control study in Europe
AU - Cassidy, Adrian
AU - Mannetje, Andrea't
AU - Van Tongeren, Martie
AU - Field, John K.
AU - Zaridze, David
AU - Szeszenia-Dabrowska, Neonila
AU - Rudnai, Peter
AU - Lissowska, Jolanta
AU - Fabianova, Eleonora
AU - Mates, Dana
AU - Bencko, Vladimir
AU - Foretova, Lenka
AU - Janout, Vladimir
AU - Fevotte, Joelle
AU - Fletcher, Tony
AU - Brennan, Paul
AU - Boffetta, Paolo
PY - 2007/1
Y1 - 2007/1
N2 - BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend <0.0001), duration of exposure (1.73; 1.26-2.39; P for trend = 0.0001) and weighted duration of exposure (1.88; 1.35-2.61; P for trend <0.0001). We did not observe any interaction beyond a multiplicative model between tobacco smoking and silica exposure. CONCLUSIONS: Our results support the hypothesis that silica is an important risk factor for lung cancer. This risk could not be explained by exposure to other occupational carcinogens or smoking, and it was present for the main histologic types of lung cancer, different sources of silica exposure, and different industrial settings.
AB - BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend <0.0001), duration of exposure (1.73; 1.26-2.39; P for trend = 0.0001) and weighted duration of exposure (1.88; 1.35-2.61; P for trend <0.0001). We did not observe any interaction beyond a multiplicative model between tobacco smoking and silica exposure. CONCLUSIONS: Our results support the hypothesis that silica is an important risk factor for lung cancer. This risk could not be explained by exposure to other occupational carcinogens or smoking, and it was present for the main histologic types of lung cancer, different sources of silica exposure, and different industrial settings.
UR - http://www.scopus.com/inward/record.url?scp=33845802494&partnerID=8YFLogxK
U2 - 10.1097/01.ede.0000248515.28903.3c
DO - 10.1097/01.ede.0000248515.28903.3c
M3 - Article
C2 - 17149143
AN - SCOPUS:33845802494
SN - 1044-3983
VL - 18
SP - 36
EP - 43
JO - Epidemiology
JF - Epidemiology
IS - 1
ER -