TY - JOUR
T1 - Occupation and risk of lymphoma
T2 - A multicentre prospective cohort study (EPIC)
AU - Neasham, David
AU - Sifi, Ahlem
AU - Nielsen, Kaspar Rene
AU - Overvad, Kim
AU - Raaschou-Nielsen, Ole
AU - Tjønneland, Anne
AU - Barricarte, Aurelio
AU - González, Carlos A.
AU - Navarro, Carmen
AU - Suarez, Laudina Rodriguez
AU - Travis, Ruth C.
AU - Key, Tim
AU - Linseisen, Jakob
AU - Kaaks, Rudolf
AU - Crosignani, Paolo
AU - Berrino, Franco
AU - Rosso, Stefano
AU - Mattiello, Amalia
AU - Vermeulen, R. C.H.
AU - Bueno-de-Mesquita, H. Bas
AU - Berglund, Göran
AU - Manjer, Jonas
AU - Zackrisson, Sophia
AU - Hallmans, Goran
AU - Malmer, Beatrice
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Masala, Giovanna
AU - Tumino, Rosario
AU - Lund, Eiliv
AU - Slimani, Nadia
AU - Ferrari, Pietro
AU - Boffetta, Paolo
AU - Vineis, Paolo
AU - Riboli, Elio
PY - 2011/1
Y1 - 2011/1
N2 - Objectives: Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods: We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results: The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion: The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.
AB - Objectives: Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods: We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results: The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion: The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.
UR - http://www.scopus.com/inward/record.url?scp=78651396162&partnerID=8YFLogxK
U2 - 10.1136/oem.2009.048173
DO - 10.1136/oem.2009.048173
M3 - Article
C2 - 20884795
AN - SCOPUS:78651396162
SN - 1351-0711
VL - 68
SP - 77
EP - 81
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 1
ER -