TY - JOUR
T1 - Occlusive Vasculopathy in Systemic Lupus Erythematosus
T2 - Association With Anticardiolipin Antibody
AU - Greisman, Stewart G.
AU - Thayaparan, Rose Sunitha
AU - Godwin, Thomas A.
AU - Lockshin, Michael D.
PY - 1991/2
Y1 - 1991/2
N2 - Patients with systemic lupus erythematosus and with antiphospholipid antibody are subject to sudden occlusion of multiple blood vessels. We describe two patients with systemic lupus erythematosus with acute, catastrophic, widespread non—inflammatory visceral vascular occlusions associated with hightiter antiphospholipid antibody. The histopathologic features clearly distinguished these patients from classic systemic lupus erythematosus vasculitis. We further suggest that, based on a probable pathogenesis related to the presence of antiphospholipid antibody, and based on the non—inflammatory vascular occlusion, steroids and other immunosuppressive medications are of limited value. Plasmapheresis along with anticoagulant therapy should be considered.
AB - Patients with systemic lupus erythematosus and with antiphospholipid antibody are subject to sudden occlusion of multiple blood vessels. We describe two patients with systemic lupus erythematosus with acute, catastrophic, widespread non—inflammatory visceral vascular occlusions associated with hightiter antiphospholipid antibody. The histopathologic features clearly distinguished these patients from classic systemic lupus erythematosus vasculitis. We further suggest that, based on a probable pathogenesis related to the presence of antiphospholipid antibody, and based on the non—inflammatory vascular occlusion, steroids and other immunosuppressive medications are of limited value. Plasmapheresis along with anticoagulant therapy should be considered.
UR - http://www.scopus.com/inward/record.url?scp=0025977538&partnerID=8YFLogxK
U2 - 10.1001/archinte.1991.00400020129028
DO - 10.1001/archinte.1991.00400020129028
M3 - Article
C2 - 1992968
AN - SCOPUS:0025977538
SN - 0003-9926
VL - 151
SP - 389
EP - 392
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 2
ER -