Occlusive Vasculopathy in Systemic Lupus Erythematosus: Association With Anticardiolipin Antibody

Stewart G. Greisman, Rose Sunitha Thayaparan, Thomas A. Godwin, Michael D. Lockshin

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Patients with systemic lupus erythematosus and with antiphospholipid antibody are subject to sudden occlusion of multiple blood vessels. We describe two patients with systemic lupus erythematosus with acute, catastrophic, widespread non—inflammatory visceral vascular occlusions associated with hightiter antiphospholipid antibody. The histopathologic features clearly distinguished these patients from classic systemic lupus erythematosus vasculitis. We further suggest that, based on a probable pathogenesis related to the presence of antiphospholipid antibody, and based on the non—inflammatory vascular occlusion, steroids and other immunosuppressive medications are of limited value. Plasmapheresis along with anticoagulant therapy should be considered.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalArchives of Internal Medicine
Volume151
Issue number2
DOIs
StatePublished - Feb 1991
Externally publishedYes

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