Obstructive lung disease after allogeneic bone marrow transplantation

  • Razelle Kurzrock
  • , Axel Zander
  • , Mahesh Kanojia
  • , Lydia Vellekoop
  • , Gary Spitzer
  • , Sundar Jagannath
  • , Sylvia Schell
  • , Lester Peters
  • , Karel Dicke

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We report the cases of 3 patients with marked dyspnea and an obstructive ventilation disorder associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation. This disorder was characterized by recurrent pulmonary infections and colonization of the lower respiratory tract by Pseudomonas aeruginosa. Two patients have shown rapidly progressive deterioration with death following due to respiratory failure. Intensive therapy with antibiotics, bronchodilators, high-dose steroids, and azathioprine was not effective in arresting the malignant course of this disorder.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalTransplantation
Volume37
Issue number2
DOIs
StatePublished - Feb 1984
Externally publishedYes

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