TY - JOUR
T1 - Obstetric complications in individuals diagnosed with autism and in healthy controls
AU - Stein, Daniel
AU - Weizman, Abraham
AU - Ring, Aliza
AU - Barak, Yoram
PY - 2006/1
Y1 - 2006/1
N2 - The aim of the present study was to investigate birth complications in Israeli autistic probands. We interviewed 206 mothers of autistic probands and 152 healthy control mothers with a structured tool encompassing prenatal, perinatal, and neonatal complications. Analysis of obstetric suboptimality, derived by summing all positive items of each of the 3 categories and dividing them by the number of patients analyzed, revealed no prenatal between-group difference. The controls had a somewhat elevated perinatal suboptimality score, whereas the autistic probands had a significantly greater neonatal suboptimality score. These differences in obstetric suboptimality were retained after controlling for the demographic parameters found different between the 2 groups (sex of participants and mothers' years of schooling). Our findings suggest that the presence of nonspecific neonatal factors, rather than the specific influence of individual severe insults, may account for the elevated neonatal suboptimality found in probands diagnosed with autism compared with healthy controls.
AB - The aim of the present study was to investigate birth complications in Israeli autistic probands. We interviewed 206 mothers of autistic probands and 152 healthy control mothers with a structured tool encompassing prenatal, perinatal, and neonatal complications. Analysis of obstetric suboptimality, derived by summing all positive items of each of the 3 categories and dividing them by the number of patients analyzed, revealed no prenatal between-group difference. The controls had a somewhat elevated perinatal suboptimality score, whereas the autistic probands had a significantly greater neonatal suboptimality score. These differences in obstetric suboptimality were retained after controlling for the demographic parameters found different between the 2 groups (sex of participants and mothers' years of schooling). Our findings suggest that the presence of nonspecific neonatal factors, rather than the specific influence of individual severe insults, may account for the elevated neonatal suboptimality found in probands diagnosed with autism compared with healthy controls.
UR - http://www.scopus.com/inward/record.url?scp=28444481376&partnerID=8YFLogxK
U2 - 10.1016/j.comppsych.2005.01.001
DO - 10.1016/j.comppsych.2005.01.001
M3 - Article
C2 - 16324905
AN - SCOPUS:28444481376
SN - 0010-440X
VL - 47
SP - 69
EP - 75
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
IS - 1
ER -